Cell Cycle G2-M DNA Damage Signaling Interactive Pathway.pdfVIP免费

KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeys14-3-3σTopoIIp21Cip1CDK714-3-3Boracdc25cdc25A/Ccdc25A/BPLK1Myt1Wee1p90RSKATM/ATRMre11NBS1Rad52Chk2c-AblPOT1TRF2Chk1DNA-PKcdc25AWIP1WIP1cdc2CyclinBp53p53MDM2MDM4MDM2AurATRIP12BRCA1BRCA1BRCA1FANCD2Rad50ReprimoGADD45Rad51HIPK2p300/PCAFSCFSCFp19ArfIRUVCriticallyShortTelomeresDNARepairCaffeine(MRN)DNARepairNuclearExclusionNuclearExclusionNucleolarSequestrationorp53StabilizationNuclearExport,UbiquitinationUbiquitinationUbiquitinationG2-PHASEM-PHASECellCycleControl:G2/MDNADamageCheckpoint©2002–2014CellSignalingTechnology,Inc.