Seeonlineversionforreferences.KingdomOrganismChaperone/ProteinDataBankIDMonomer(kDa)/OligomericStateCochaperone/CofactorSubcellularLocalization/ActivityHsp70SystemEubacteriaE.coliDnaK/1DKG;1DKZ69/monomerDnaJ,GrpE,ClpBCytosol/foldingofnascentproteins;exportofsomeproteins;reactivatesheat-inactivatedproteins;facilitatesabnormalproteindegradation;workswithClpBinproteinaggregatedisassembly;regulatesheat-shockresponse.ArchaeaMethanosarcinaeDnaK67/monomerDnaJ,GrpECytosol/similartobacterialDnaK.EukaryotesS.cerevisiaeSsa1-470/monomerYdj1,Sis1,Sti1,Snl1,Fes1,Sse1/2,Cns1Cytosol/foldingofnewlysynthesizedproteins;proteintransportintoER,mitochondria.Ssb1,266/monomerZuotin,Sse1/2,Ssz1Cytosol/foldingofribosome-boundnascentchains.Pdr13p/Ssz158/heterodimerZuotinCytosol/Zuotincofactor;modifiesZuotin-Ssbinteraction;foldingofnascentchainsonribosomes.Sse1/277/monomer;heterodimerSsa1,Ssb1,Sis1Cytosol/nucleotideexchangefactorforSsaandSsbHsp70s;participatesinproteinfoldingandrefolding.MammalsHsc70,Hsp70/1YUW71/monomerHsp40,Hop,Bag1-5,Hip,HspBP1,CHIP,SGT,TPR1,Tom70,Hsp110homologsCytosol/mediatesnascentpolypeptidefolding;proteintransportintoER,mitochondria,nucleus;promoteslysosomaldegradationofcytosolicproteins;inhibitspolyglutaminefibrilformation.Hsp11097/monomerHsp70Cytosol/preventsproteinaggregationunderstress;similartoS.cerevisiaeSse1/2.Hsp70L155/heterodimerMPP11Cytosol/foldingofnascentchainsonribosomes;similartoS.cerevisiaeSsz1.S.cerevisiaeKar274/monomerSec63,Scj1,Jem1,Lhs1,Sil1/Sls1ER/proteintranslocationintoER;bindstounassembled/misfoldedERproteinsubunits;regulatesunfoldedproteinresponse.Lhs197Kar2ER/Hsp110homolog;nucleotideexchangefactorofKar2.MammalsBip/Grp7872/monomerGrp170,Sil1/Sls1ER/similartoKar2;multimericERproteinassembly.S.cerevisiaeSsc171/monomerTim14,Tim16,Tim44,Mdj1,Mge1Mitochondria/proteintranslocationandfoldinginmitochondria.Ssc3/Ecm1070/monomerMge1Mitochondria/assistssomemitochondrialproteincomplexassembly;mediatesfoldingofimportedproteins?Ssq172/monomerJac1,Mge1Mitoc...
