FullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=kaup20AutophagyISSN:1554-8627(Print)1554-8635(Online)Journalhomepage:http://www.tandfonline.com/loi/kaup20ActivationofferritinophagyisrequiredfortheRNA-bindingproteinELAVL1/HuRtoregulateferroptosisinhepaticstellatecellsZiliZhang,ZhenYao,LingWang,HaiDing,JiangjuanShao,AnpingChen,FengZhang&ShizhongZhengTocitethisarticle:ZiliZhang,ZhenYao,LingWang,HaiDing,JiangjuanShao,AnpingChen,FengZhang&ShizhongZheng(2018)ActivationofferritinophagyisrequiredfortheRNA-bindingproteinELAVL1/HuRtoregulateferroptosisinhepaticstellatecells,Autophagy,14:12,2083-2103,DOI:10.1080/15548627.2018.1503146Tolinktothisarticle:https://doi.org/10.1080/15548627.2018.1503146ViewsupplementarymaterialAcceptedauthorversionpostedonline:06Aug2018.Publishedonline:21Aug2018.SubmityourarticletothisjournalArticleviews:702ViewCrossmarkdataRESEARCHPAPER-BASICSCIENCEActivationofferritinophagyisrequiredfortheRNA-bindingproteinELAVL1/HuRtoregulateferroptosisinhepaticstellatecellsZiliZhanga*,ZhenYaoa*,LingWanga*,HaiDingb,JiangjuanShaoa,c,d,AnpingChene,FengZhanga,c,d,andShizhongZhenga,c,daDepartmentofPharmacology,SchoolofPharmacy,NanjingUniversityofChineseMedicine,Nanjing,China;bDepartmentofPathogenicbiologyandImmunology,MedicalSchool,SoutheastUniversity,Nanjing,China;cJiangsuKeyLaboratoryforPharmacologyandSafetyEvaluationofChineseMateriaMedica,NanjingUniversityofChineseMedicine,Nanjing,China;dJiangsuKeyLaboratoryofTherapeuticMaterialofChineseMedicine,NanjingUniversityofChineseMedicine,Nanjing,China;eDepartmentofPathology,SchoolofMedicine,SaintLouisUniversity,StLouis,MO,USAABSTRACTFerroptosisisarecentlyrecognizedformofregulatedcelldeaththatischaracterizedbylipidperoxida-tion.However,themolecularmechanismsregulatingferroptosisarelargelyunknown.Inthisstudy,wereportthattheRNA-bindingproteinELAVL1/HuRplaysacrucialroleinregulatingferroptosisinliverfibrosis.Uponexposuretoferroptosis-inducingcompounds,ELAVL1prot...
