Seeonlineversionforlegendandreferences.SnapShot:NonmotorProteinsinSpindleAssemblyAmityL.ManningandDuaneA.ComptonDepartmentofBiochemistry,DartmouthMedicalSchool,Hanover,NHandNorrisCottonCancerCenter,Lebanon,NH03755,USA694Cell134,August22,2008©2008ElsevierInc.DOI10.1016/j.cell.2008.08.001ProteinnamespecieslocalizationfunctioninspindleAssemblymicrotubulenucleation/stabilizationDGT/augmincomplexHuman,flySpindlemicrotubulesBoostsmicrotubulenumberbyregulatingγ-tubulinNuSAPHuman,mouse,frogCentralspindleNucleation,stabilization,andbundlingofmicrotubulesnearchromo-somes*RHAMM/HMMRHuman,mouse,frog(XRHAMM)Centrosomes,spindlepoles,spindlemidbodyNucleatesandstabilizesmicrotubulesatspindlepoles;influencescyclinB1activity*TACC1-3Human,mouse,fly(D-TACC),worm(TAC-1),frog(Maskin),Sp(Alp7)Centrosomes,spindlepolesPromotesmicrotubulenucleationandstabilizationatspindlepoles*TOGpHuman,mouse,fly(Minispindles/Msps),worm(ZYG-9),frog(XMAP215/Dis1),Sc(Stu2),Sp(Dis1/Alp14)Centrosomes,spindlepolesPromotescentrosomeandspindlepolestability;promotesplus-endmicrotubuledynamicsmicrotubulecrosslinking/stabilizationAstrinHuman,mouse(Spag5)Spindlepoles,kinetochoresCrosslinksandstabilizesmicrotubulesatspindlepolesandkinetochores;stabilizescohesin*HURP/DLG7Human,mouse,fly,worm,frog,ScKinetochorefibers,mostintensenearkinetochoresStabilizeskinetochorefiber;influenceschromosomealignment*NuMAHuman,mouse,fly(Mud/Asp1),frogSpindlepolesFormation/maintenanceofspindlepoles;inhibitsAPC/Catspindlepoles*Prc1Human,mouse,fly(Fascetto/Feo),worm(SPD-1),frog,Sc(Ase1),Sp(Ase1)Centralspindle,spindlemidbodyStabilizesanaphasespindleelongationbycrosslinkingantiparallelspindlemidzonemicrotubulesTektin2Human,mouse,fly,worm,frog,Centrosomes,midbodyBundlesmicrotubulesofthemidbodytoallowcytokinesis*TPX2Human,mouse,fly(Asp1),worm(TPXL-1),frogSpindlepoles,spindlemidbodyPromotesmicrotubulenucleationandcentrosomeintegrity;activatesAuroraA;crosslinksmicrotubulesatspindlepolesmicrotubuleseverance/destabilization*DDA3Human,mouseSpind...
