Seeonlineversionforlegendandreferences.586Cell137,May1,2009©2009ElsevierInc.DOI10.1016/j.cell.2009.04.040SnapShot:MicroRNAsinCancerRiccardoSpizzo,MilenaS.Nicoloso,CarloM.Croce,andGeorgeA.CalinExperimentalTherapeuticsandCancerGenetics,MDAndersonCancerCenter,Houston,TX77030andComprehensiveCancerCenter,OhioStateUniversity,Columbus,OH43210,USAHumanMicroRnAsDeregulationincancerMolecularMechanisms,TargetsDiagnostic,PrognosticMarkerlet-7family(various)Downregulatedinlung,breast,gastric,ovary,prostateandcoloncancers,CLL,leiomyomas;miR-98downregulatedinheadandneckcancer.Pointmutationinlet-7etranscriptaffectsmiRNAmaturation.Represscellproliferationandgrowth.let-7fpromotesangiogenesis.Targets:CCND1,CDC25a,CDC34,CDK6,CRD-BP,DICER,HMGA2,HOXA9,IMP-1,ITGB3,MYC,RAS,TLR4.SNPinK-RAS3′UTR(let-7abindingsite)increasesNSCLCrisk(cancerpredisposition).Lowexpressionoflet-7a-2inlungandovariancancerandoflet-7binuvealmelanoma(poorprognosis).let-7iaffectschemotherapypotency.Intranasaldeliveryoflet-7areducesgrowthofRas-inducedmouselungtumors.let-7a-3hypomethylatedinlungadenocarcinoma;overexpressedinAMLlet-7arepressesNF2anddecreaseschemotherapy-inducedapoptosisinvitro.Target:CASP3.miR-10b(2q31.1,intergenic)Downregulatedinbreastcancer.Overexpressedinmetastaticbreastcancer(doesnotpredictmetastasisinearlystages).Activatescellmigrationandextracellularmatrixremodeling.Target:HOXD10.miR-15a,miR-16-1cluster(13q14.3,intron4noncodingRNADLEU2)DownregulatedinCLL,DLBCL,multiplemyeloma,pituitaryadenoma,prostateandpancreaticcancer.GermlinemutationsinB-CLLpatientsandinNZBmicethatdevelopCLL-likedisorder.Induceapoptosisinleukemiacells.miR-16regulatescellcyclebydownregulatingG0/G1proteins.Targets:BCL2,CAPRIN1,CARD10,CCND1,CDK6,CDC27,CGI-38,CYCE,DMTF1,HMGA2,MCL1,MYB,NGN2,VEGF,WNT3A.LowexpressionofmiR-15a,miR-16indenovoCLL(goodprognosis).miR-16modulateschemotherapypotency,sensitivitytovincristineingastriccancer(predictsresponse).UpregulatedinnasopharyngealcarcinomaTarget:BRCA1miR-17,miR-18a,miR-19a,miR-20a,miR-...
