Seediscussions,stats,andauthorprofilesforthispublicationat:https://www.researchgate.net/publication/283012884Microenvironment-inducedPTENlossbyexosomalmicroRNAprimesbrainmetastasisoutgrowthArticleinNature·October2015DOI:10.1038/nature15376CITATIONS327READS54822authors,including:Someoftheauthorsofthispublicationarealsoworkingontheserelatedprojects:CloudmanufacturingViewprojectMicrofluidicandimagingViewprojectLinZhangBeihangUniversity(BUAA)200PUBLICATIONS4,315CITATIONSSEEPROFILESiyuanZhangUniversityofNotreDame46PUBLICATIONS2,490CITATIONSSEEPROFILEJunYaoUniversityofTexasMDAndersonCancerCenter84PUBLICATIONS11,746CITATIONSSEEPROFILEwen-chienHuangMackayMemorialHospital14PUBLICATIONS937CITATIONSSEEPROFILEAllcontentfollowingthispagewasuploadedbyJodiM.Saunuson21January2016.Theuserhasrequestedenhancementofthedownloadedfile.LETTERdoi:10.1038/nature15376Microenvironment-inducedPTENlossbyexosomalmicroRNAprimesbrainmetastasisoutgrowthLinZhang1,2*,SiyuanZhang1,3*,JunYao1,FrankJ.Lowery1,2,QinglingZhang1,Wen-ChienHuang1,PingLi1,MinLi1,XiaoWang1,ChenyuZhang1,HaiWang1,KennethEllis1,MujeeburahimanCheerathodi4,JosephH.McCarty4,DianePalmieri5,JodiSaunus6,SunilLakhani6,7,8,SuyunHuang4,AysegulA.Sahin9,KennethD.Aldape9,PatriciaS.Steeg5&DihuaYu1,2,10Thedevelopmentoflife-threateningcancermetastasesatdistantorgansrequiresdisseminatedtumourcells’adaptationto,andco-evolutionwith,thedrasticallydifferentmicroenvironmentsofmetastaticsites1.Cancercellsofcommonoriginmanifestdistinctgeneexpressionpatternsaftermetastasizingtodifferentorgans2.Clearly,thedynamicinteractionbetweenmetastatictumourcellsandextrinsicsignalsatindividualmetastaticorgansitescriticallyeffectsthesubsequentmetastaticoutgrowth3,4.Yet,itisunclearwhenandhowdisseminatedtumourcellsacquiretheessentialtraitsfromthemicroenvironmentofmetastaticorgansthatprimetheirsubsequentoutgrowth.HereweshowthatbothhumanandmousetumourcellswithnormalexpressionofPTEN,animport-anttumoursuppressor,losePTENexpressionafterdisseminationtothebrain,butnottoot...
