KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysHistoneH3CREBSRFPPARγERElk-1Stat1/3c-Myc/N-MycMSK1/2p90RSKp90RSKp90RSKErk1/2Erk1/2Erk1/2MNK1/2cPLA2nNosPLD1MEK1/2PP1/PP2AtB-RafB-RafPKAc-Rafc-RafPKCPLCγSrcPYK2PAKLKB1AMPKSprySpredTpl2/Cot1PI3KFAKGRB2GRB2RasRacRap1CRK14-3-3IntegrinsMEK1MP1Erk1LAMTOR2C-TAK1IMPRACK1ATF1c-FosEtsPax6UBFMKP-1/2cdc25MKP-3KSR1/2c-FosFoxO3ERαATF4MITFMad1Nur77ETV1TIF1AeIF4BMETTL1eEF2KGSK-3rpS6TCPβIκBαBADDAPKC/EBPβMyt1BUB1FilaminARaptorER81HMGN1YB1TIF1Ap27KIP1TSC2WAVE-2BimTalShcFRS2IRSSOSSOSSOSEPACIonChannels[Ca2+]RTKsRTKsC3GCASFynPaxPEA-15[cAMP][Ca2+]TranslationControlIonChannels,ReceptorsNucleusCytoplasmHeterodimerFMKSL0101BI-D1870TranscriptionPD98059U0126AZD6244LateEndosomeCellAdhesionMigrationCa+2-regulatedExocytosismTORSignalingCytoplasmicAnchoringMAPK/ErkinGrowthandDifferentiation©2003–2014CellSignalingTechnology,Inc.
