Understandingthetumorimmunemicroenvironment(TIME)foreffectivetherapyMikhailBinnewies1,EdwardW.Roberts1,KellyKersten1,VincentChan2,DouglasF.Fearon3,MiriamMerad4,LisaM.Coussens5,DmitryI.Gabrilovich6,SuzanneOstrand-Rosenberg7,8,CatherineC.Hedrick9,RobertH.Vonderheide10,MikaelJ.Pittet11,RakeshK.Jain12,WeipingZou13,T.KevinHowcroft14,ElisaC.Woodhouse14,RobertA.Weinberg15,*,andMatthewF.Krummel1,2,*1DepartmentofPathology,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA,USA2UCSFImmunoprofilerInitiative,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA,USA3ColdSpringHarborLaboratory,ColdSpringHarbor,NY,USA4PrecisionImmunologyInstitute,IcahnSchoolofMedicineatMountSinai,NewYork,NY,USA5DepartmentofCell,Developmental&CancerBiology,OregonHealthandScienceUniversity,Portland,OR,USA6TheWistarInstitute,Philadelphia,PA,USA7DepartmentofBiologicalSciences,UniversityofMarylandBaltimoreCounty,Baltimore,MD,USA8HuntsmanCancerInstituteandDepartmentofPathology,UniversityofUtah,SaltLakeCity,UT,USA9DivisionofInflammationBiology,LaJollaInstituteforAllergyandImmunology,LaJolla,CA,USA10DepartmentofMedicine,AbramsonCancerCenter,UniversityofPennsylvania,Philadelphia,PA,USA11CenterforSystemsBiology,MassachusettsGeneralHospital,Boston,MA,USA12EdwinL.SteeleLaboratoriesforTumorBiology,DepartmentofRadiationOncology,MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,MA,USA13DepartmentofSurgery,UniversityofMichiganSchoolofMedicine,AnnArbor,MI,USA14DivisionofCancerBiology,NCI,NIH,Bethesda,MD,USA15WhiteheadInstituteforBiomedicalResearch,Cambridge,MA,USAAbstractReprintsandpermissionsinformationisavailableatwww.nature.com/reprints.*CorrespondenceshouldbeaddressedtoR.W.orM.K.weinberg@wi.mit.edu;matthew.krummel@ucsf.edu.CompetinginterestsTheauthorsdeclarenocompetinginterests.Publisher’snote:SpringerNatureremainsneutralwithregardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations.HHSPublicAccessAuthormanuscriptNatMed.Authormanuscript;availableinPMC2018June13.Publishedinfinaleditedfor...
