ContentslistsavailableatScienceDirectAgeingResearchReviewsjournalhomepage:www.elsevier.com/locate/arrReviewLncRNA:SheddinglightonmechanismsandopportunitiesinfibrosisandagingZhiYanga,b,1,ShuaiJiangc,1,JiajiaShanga,YutingJianga,YuDaia,BaopingXua,YuanYua,ZhenxingLiangd,YangYanga,⁎aKeyLaboratoryofResourceBiologyandBiotechnologyinWesternChina,MinistryofEducation,FacultyofLifeSciences,NorthwestUniversity,229TaibaiNorthRoad,Xi’an710069,ChinabDepartmentofCardiovascularSurgery,GeneralHospitalofGuangzhouMilitaryCommandofPLA,111LiuhuaRoad,GuangZhou510010,ChinacDepartmentofAerospaceMedicine,TheFourthMilitaryMedicalUniversity,169ChangleWestRoad,Xi’an710032,ChinadDepartmentofCardiothoracicSurgery,TheFirstAffiliatedHospitalofZhengzhouUniversity,1JiansheEast,Zhengzhou450052,ChinaARTICLEINFOKeywords:LongnoncodingRNAsFibrosisAgingABSTRACTFibrosisisuniversallyobservedinmultipleaging-relateddiseasesandprogressionsandischaracterizedbyexcessaccumulationoftheextracellularmatrix.Fibrosisoccursinvarioushumanorgansandeventuallyresultsinorganfailure.NoncodingRNAs(ncRNAs)haveemergedasessentialregulatorsofcellularsignalingandre-levanthumandiseases.Inparticular,theenigmaticclassoflongnoncodingRNAs(lncRNAs)isakindofnon-codingRNAthatislongerthan200nucleotidesanddoesnotpossessproteincodingability.LncRNAshavebeenidentifiedtoexertbothpromotiveandinhibitoryeffectsonthemultifacetedprocessesoffibrosis.AgrowingbodyofstudieshasrevealedthatlncRNAsareinvolvedinfibrosisinvariousorgans,includingtheliver,heart,lung,andkidney.AslncRNAshavebeenincreasinglyidentified,theyhavebecomepromisingtargetsforanti-fibrosistherapies.ThisreviewsystematicallyhighlightstherecentadvancesregardingtherolesoflncRNAsinfibrosisandshedslightontheuseoflncRNAsasapotentialtreatmentforfibrosis.1.IntroductionAgingisacomplicatedprogressioninvolvingattenuatedcellularfunctionandweakenedstressresistance(Detienneetal.,2018)andithasbeengenerallyrecognizedasthestartingpointforseveralchronicdiseases,includingneurodegenerativedisorders(Lveta...
