Biol.Rev.(2019),pp.000–000.1doi:10.1111/brv.12515MolecularinterplayofautophagyandendocytosisinhumanhealthanddiseasesKewalK.Mahapatra,DebasnaP.Panigrahi,PrakashP.Praharaj,ChandraS.Bhol,SrimantaPatra,SoumyaR.Mishra,BishnuP.BeheraandSujitK.Bhutia∗DepartmentofLifeScience,NationalInstituteofTechnologyRourkela,Sundergarh,Odisha769008,IndiaABSTRACTAutophagy,anevolutionarilyconservedprocessformaintainingthephysio-metabolicequilibriumofcells,sharesmanycommoneffectorproteinswithendocytosis.Forexample,tetheringproteinsinvolvedinfusionlikeRas-likeGTPases(Rabs),solubleN-ethylmaleimidesensitivefactorattachmentproteinreceptors(SNAREs),lysosomal-associatedmembraneprotein(LAMP),andendosomalsortingcomplexrequiredfortransport(ESCRT)haveadualroleinendocytosisandautophagy,andthetraffickingroutesoftheseprocessesconvergeatlysosomes.Thesecommoneffectorsindicateanassociationbetweenbuddingandfusionofmembrane-boundvesiclesthatmayhaveasubstantialroleinautophagiclysosomereformation,bysensingcellularstresslevels.Therefore,autophagy–endocytosiscrosstalkmaybesignificantandimplicatesanovelendocyticregulatorypathwayofautophagy.Moreover,endocytosishasapivotalroleintheintakeofsignallingmolecules,whichinturnactivatescascadesthatcanresultinpathophysiologicalconditions.Thisreviewdiscussesthebasicmechanismsofthiscrosstalkanditsimplicationsinordertoidentifypotentialnoveltherapeutictargetsforvarioushumandiseases.Keywords:autophagy,endocytosis,autophagosome,amphisome,lysosome.CONTENTSI.Introduction..............................................................................................2II.Autophagyanditsregulation.............................................................................2III.Overviewoftheendocyticpathway......................................................................4IV.Theinterplayofconventionalandnon-conventionalpathwaysinautophagydynamics.................4V.Convergenceofautophagyandendocytosis..............................................................5(1)Processesinv...
