AcceptedManuscriptOxidativeStressandEpigeneticModificationsinthePathogenesisofDiabeticRetinopathyRenuA.Kowluru,PhD,AnjanKowluru,ManishMishra,BinitKumarPII:S1350-9462(15)00031-2DOI:10.1016/j.preteyeres.2015.05.001Reference:JPRR590Toappearin:ProgressinRetinalandEyeResearchReceivedDate:24February2015RevisedDate:29April2015AcceptedDate:1May2015Pleasecitethisarticleas:Kowluru,R.A.,Kowluru,A.,Mishra,M.,Kumar,B.,OxidativeStressandEpigeneticModificationsinthePathogenesisofDiabeticRetinopathy,ProgressinRetinalandEyeResearch(2015),doi:10.1016/j.preteyeres.2015.05.001.ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.MANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPT1OxidativeStressandEpigeneticModificationsinthePathogenesisofDiabeticRetinopathyRenuA.Kowlurua,b*,AnjanKowluruc,d,ManishMishraa,BinitKumaraDepartmentofOphthalmologya,Anatomy/CellBiologyb,PharmaceuticalSciencesc,WayneStateUniversity,andJohnDDingellVAMedicalCenterd,Detroit,MI*CorrespondingAuthorRenuA.Kowluru,PhDDepartmentofOphthalmology/AnatomyCellBiologyKresgeEyeInstitute,WayneStateUniversityDetroit,MI48201Telephone:001-313-993-6714E-Mail:rkowluru@med.wayne.eduMANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPT2AbstractDiabeticretinopathyremainsthemajorcauseofblindnessamongworkingageadults.Althoughanumberofmetabolicabnormalitieshavebeenassociatedwithitsdevelopment,duetocomplexnatureofthismulti-factorialdisease,alinkbetweenanyspecificabnormalityanddiabeticretinopathyremainslargelyspeculative.Diabetesincreasesoxidativestressintheretinaanditscapillarycells,andoverwhelmingevidencesuggestsabidirectionalrelationshipbetweenoxidativestressandothermajormetabolicabnormalitiesimplicatedinthedevelopmentofdiabeticretinopa...
