KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysCasp-9Casp-3BaktBIDtBIDBimBmfBmfBIDBaxBaxBakBaxBaxBadBcl-2Bcl-2Bcl-2Bcl-2PumaBcl-xLBcl-xLPKCErk1/2p90RSKp70S6KAktPKA14-3-3Bad14-3-3BadApaf-1CytocArtsXIAPSmac/DiabloAIFATM/ATRJNKJNKp53PI3KBimCasp-8,-10FADDubBakMcl-1HECTH9HECTH9PIDDRAIDDCaMKIIHrkDP5HrkDP5DLC2LC8HSP60HtrA2EndoGING2SirT2ARD1NatAFas/CD95FasLNoxaMcl-1Calcineurin[NAD]Casp-2MicrotubulesAcetyl-CoAApoptosisDNADamageGenotoxicStressCytosolicSequestrationBcl-2FamilySurvivalFactors:GrowthFactors,Cytokines,etc.DeathStimuli:SurvivalFactorWithdrawalPro-ApoptoticPro-SurvivalMitochondrialControlofApoptosis©2003–2014CellSignalingTechnology,Inc.
