SnapShot:ActinRegulatorsIAnoshaD.SiripalaandMatthewD.WelchDepartmentofMolecularandCellBiology,UniversityofCalifornia,Berkeley,CA94720,USAProteinFamilyBiochemicalFunctionRepresentativeProteinsH.sapiensD.melanogasterC.elegansA.thalianaS.cerevisiaeActinNucleatorsForminsassociateswithbarbedends,promotesnucleation*hDia1,2,3,FHOD1,2,3,4,DAAM1,2,FMN1,2,FRL1,2,3,INF1,2,DelphilinDiaphanous/Dia,Cappucino/FMN,DAAM,FRL,FHOD,INFDia/CYK-1,DAAM,FRL,FHOD,INFAtFH1-4,5,6-21Bni1,Bnr1SpirnucleatesunbranchedfilamentsSpir-1,Spir-2Spir/spireArp2/3complexpolymerizesY-branchedfilamentnetworksARP2,ARP3,ARPC1A,1B,2,3,4,5,5LARP2,ARP3,ARPC1,2,3A,3B,4,5,5LARX1-7ARP2,ARP3,ARPC1-5Arp2,Arp3,Arc40,35,18,19,15Arp2/3complexregulatorsCARMILlinkscappingprotein,Arp2/3andmyosinICARMILDCarmil†Q21301CoroninbindsF-actinandArp2/3complex,enhancesactindepolymerizationcoronin1A,B,C;2A,B;7Coro/Coronin,Dpod1COR-1,POD-1Crn1Cortactinactivates/modulatesArp2/3complex,bindsF-actincortactin,HS1DCortactinSCAR/WAVEfamilyactivatesArp2/3complexSCAR1,SCAR2,SCAR3SCARWVE-1AtSCAR1,2,3,4WASPfamilyactivatesArp2/3complex*WASP,N-WASPWASpWSP-1Las17/Bee1G-ActinBindingProteinsCAP/Srv2recyclesactinmonomersCAP1,CAP2Actup/CapuletCAS-1AtCAP1Srv2Profilinpromotesactinmonomeradditionatbarbedendsprofilin1,2,3,4ChickadeePFN1,2,3PRF1-3(vegetative),PRF4-5(reproductive)Pfy1Thymosinβ4sequestersG-actinthymosinβ4CiboulotTTH-1Verprolin/WIPbindsactinmonomers,WASPWIP,WIRE/WICH,CR16†Q8MLU0WIP-1Vrp1F-ActinBindingProteinsEna/VASPfamilyantagonizesCapZcappingatfilamentends,recruitsprofilinMena,VASP,EVLEnabledUNC-34MIMbindsbothG-andF-actin,mayregulatenucleation-promotingfactorsMIMPointedEndCappingProteinsTropomodulin/Tmodcapspointedends,bindstropomyosinTmod1,2,3,4,Lmod1,2,3SanpodoTMD-1,TMD-2BarbedEndCappingProteinsAIP1promotesdepolymerizationbyADF/cofilinAIP1/WDR1Aip1AIP-1/UNC-78AtAIP1Aip1CapGcapsbarbedends(calcium-dependent)capGCapGCapZ/cappingprotein/β-actininheterodimercapsbarbedendscapZ(A1-3,B1-2)CapZ(cpa,cpb)CAP-1,CAP-2AtCPA,AtCPBCap1,Cap2Eps8ca...
