CellMetabolismReviewMacrophagesandMetabolismintheTumorMicroenvironmentIlioVitale,1,2,3GwenolaManic,4LisaM.Coussens,5GuidoKroemer,6,7,8,9,10,11,12,13,*andLorenzoGalluzzi6,14,15,16,17,*1DepartmentofBiology,UniversityofRome‘‘TorVergata’’,Rome,Italy2ItalianInstituteforGenomicMedicine(IIGM),Turin,Italy3CandioloCancerInstitute-FPO,IRCCS,Candiolo,Italy4IRCSS-ReginaElenaNationalCancerInstitute,Rome,Italy5DepartmentofCellDevelopment&CancerBiology,KnightCancerInstitute,OregonHealthandScienceUniversity,Portland,OR,USA6Universite´ParisDescartes,Paris,France7Universite´PierreetMarieCurie,Paris,France8E´quipe11labellise´eLigueNationalecontreleCancer,CentredeRecherchedesCordeliers,Paris,France9INSERM,U1138,Paris,France10MetabolomicsandCellBiologyPlatforms,GustaveRoussyCancerCampus,Villejuif,France11PoˆledeBiologie,HoˆpitalEurope´enGeorgesPompidou,AP-HP,Paris,France12SuzhouInstituteforSystemsMedicine,ChineseAcademyofSciences,Suzhou,China13DepartmentofWomen’sandChildren’sHealth,KarolinskaUniversityHospital,Stockholm,Sweden14DepartmentofRadiationOncology,WeillCornellMedicalCollege,NewYork,NY,USA15SandraandEdwardMeyerCancerCenter,NewYork,NY,USA16DepartmentofDermatology,YaleUniversitySchoolofMedicine,NewHaven,CT,USA17LeadContact*Correspondence:kroemer@orange.fr(G.K.),deadoc80@gmail.com(L.G.)https://doi.org/10.1016/j.cmet.2019.06.001Tumor-associatedmacrophages(TAMs)constituteaplasticandheterogeneouscellpopulationofthetumormicroenvironment(TME)thatcanaccountforupto50%ofsomesolidneoplasms.Mostoften,TAMssupportdiseaseprogressionandresistancetotherapybyprovidingmalignantcellswithtrophicandnutritionalsupport.However,TAMscanmediateantineoplasticeffects,especiallyinresponsetopharmacologicalagentsthatboosttheirphagocyticandoxidativefunctions.Thus,TAMsandtheirimpactontheoverallmetabolicprofileoftheTMEhaveamajorinfluenceontumorprogressionandresistancetotherapy,defactoconstitutingpromisingtargetsforthedevelopmentofnovelanticanceragents.Here,wediscussthemeta-boliccircuitrieswherebyT...
