GE53CH03_AlbertiARjats.clsAugust13,201916:16AnnualReviewofGeneticsLiquid–LiquidPhaseSeparationinDiseaseSimonAlberti1,2andDorotheeDormann3,41BiotechnologyCenter(BIOTEC),CenterforMolecularandCellularBioengineering(CMCB),TechnischeUniversitätDresden,01307Dresden,Germany;email:Simon.Alberti@tu-dresden.de2MaxPlanckInstituteofMolecularCellBiologyandGenetics,01307Dresden,Germany3BioMedicalCenter(BMC),Ludwig-Maximilians-UniversityMunich,82152Planegg-Martinsried,Germany;email:dorothee.dormann@med.uni-muenchen.de4MunichClusterforSystemsNeurology(SyNergy),Ludwig-Maximilians-UniversityMunich,81377Munich,GermanyAnnu.Rev.Genet.2019.53:3.1–3.24TheAnnualReviewofGeneticsisonlineatgenet.annualreviews.orghttps://doi.org/10.1146/annurev-genet-112618-043527Copyright©2019byAnnualReviews.AllrightsreservedKeywordsphaseseparation,membranelessorganelle,biomolecularcondensate,cancer,neurodegeneration,infectiousdiseaseAbstractWehavemaderapidprogressinrecentyearsinidentifyingthegeneticcausesofmanyhumandiseases.However,despitethisrecentprogress,ourmechanisticunderstandingofthesediseasesisoftenincomplete.Thisisaproblembecauseitlimitsourabilitytodevelopeffectivediseasetreatments.Toovercomethislimitation,weneednewconceptstodescribeandcom-prehendthecomplexmechanismsunderlyinghumandiseases.Condensateformationbyphaseseparationemergesasanewprincipletoexplaintheorganizationoflivingcells.Inthisreview,wepresentemergingevidencethataberrantformsofcondensatesareassociatedwithmanyhumandiseases,includingcancer,neurodegeneration,andinfectiousdiseases.Weexaminediseasemechanismsdrivenbyaberrantcondensates,andwepointoutopportunitiesfortherapeuticinterventions.Weconcludethatphaseseparationprovidesausefulnewframeworktounderstandandfightsomeofthemostseverehumandiseases.3.1ReviewinAdvancefirstpostedonAugust20,2019.(Changesmaystilloccurbeforefinalpublication.)Annu.Rev.Genet.2019.53.Downloadedfromwww.annualreviews.orgAccessprovidedbyCarletonUniversity(Canada)on08/21/19.Forpersonaluseonly.GE53CH03_AlbertiARjats.cl...
