LysineMethyltransferaseSubstratesLysineMethylationDynamicRegulationLysineMethylationofNon-histoneProteins:AnExpandingLandscapeDynamicp53MethylationRas-MAPKSignalingMethyllysineReadersKMTHistonesNon-histonesNSD3H3(K36)Kme0&1EGFR(K721)Kme0MBDHistonesNon-histonesBINDINGSITEme1/2/3HP1βMPP8H3(K9me3)H3(K9me3)DNA-PKcs(K1150/2746/3248me2/3)DNMT3a(K44me2)GLP(K205me2)MBTK370me2GrowthfactorbindingK382me2K382meK373me2K372meK370meK260ororL3MBTL1H1β(K26me2)p53(K382me2)RB1(K860me)TudorChromo53BP1PHF20H4(K20me1/2)H3(K4me2)H4(K20me2)p53(K370/382me2)RB1(K810me1/2)p53(K370/382me2)ESR(K235me2)SETD1AH3(K4)Kme0,1&2HSP70(K561)Kme1SETD1BH3(K4)Kme0,1&2TAT(K50/51)Kme2SETD7H3(K4)Kme0P53(K372)RB1(K810/873)E2F1(K185)RELA(K37/314/315)TAF7(K5)TAF10(K189)YAP(K494)STAT3(K140)FoxO3(K270/271)MYPT1(K442)IRF1/2(K126/134)PIAS2(K2076)ESR(K302)AR(K630/632)FXR(K206)GFI-1B(K8)CENPC(K414)MECP2(K347)PARP1(K508)PPARBP(K1006)DNMT1(K142/1094)Suv39H1(K105/123)PCAF(K78/89)SIRT1(K233/235/236/238)TTK(K708/710)CULLIN1(K73)TAT(K51)ZDHHC8(K300)AKAP6(K604)Kme0Kme0Kme0Kme0Kme0Kme0Kme0Kme1Kme0Kme0Kme0&1Kme1Kme0Kme0undefnedKme1Kme0Kme0Kme0undefnedKme0Kme0Kme0Kme0undefnedundefnedKme0Kme0undefnedSETD6–RELA(K310)Kme0METTL21B––EEF1A(K165)Kme2METTL21D–VCP/p97(K315)Kme2METTL22–KIN17(K135)Kme2SETDB1EZH2H3(K9)H3(K27)Kme0,1&2Kme1&2P53(K370)STAT3(K180)GATA4(K299)RORα(K38)Kme1undefnedKme0Kme0GLPH3(K9)H1.2(K187)Kme0&1Kme0&1P53(K373)DNMT3a(K44)GLP(K205)Kme1Kme1Kme1SETD8H4(K20)Kme0P53(K382)PCNA(K248)Numb(K158/163)Kme0Kme0Kme0&1SMYD3H4K5Kme0,1&2MAP3K2(K260)VEGFR(K831)Kme0,1&2Kme1SMYD2–P53(K370)RB1(K810/860)ESR(K266)HSP90(K209/615)MAPKAPK3(K355)Kme0Kme0undefnedKme0Kme0METTL10METTL21A––EF1A(K318)HSP72(K561)HSP70-2(K563)GRP78(K585)HSP70B(K563)HSC70(K561)Kme2Kme2Kme2Kme2Kme2Kme2G9aH3(K9)H1.2(K187)Kme0&1Kme0&1P53(K373)MEF2D(K276)MTA1(K532)RuvBL2(K67)C/EBP(K39)MyoD(K104)WIZ(K305)KLF12(K313)EED(K66/197/268/284)DNMT1(K70)DNMT3a(K44)G9a(K165/239)GLP(K174)GLP(K205)MAM(K16)CDYL1(K135)HDAC1(K432)ACINUS(K654)Reptin(K67)Kme1Kme0&1Kme1Kme...
