MethylaseYeast(S.cerevisiae)DrosophilaMammalsSubstrateKMT1H3K9KMT2KMT6H3K27H3K4KMT4H3K79KMT3H3K36KMT5H4K20Biochemical/biologicalpropertiesHeterochromatinformation/silencingG9aKMT1CSu(var)3-9KMT1A/BSUV39H1/2KMT1A/BG9AGLPKMT1C/DCAF1HP1SETDB1KMT1ESETDB1ATF7IPySet1/COMPASSCps30Cps60Cps35Set1Cps25Cps50Cps40Activetranscription;homeoticgeneexpression;nuclearhormonereceptorsignalingWdr82WdsAsh2Cxxc1Set1Dpy30Rbbp5KMT2F/GMnn1WdsAsh2TrxDpy30Rbbp5KMT2A/BHcfPtipWdsAsh2TrrDpy30Rbbp5UtxPa1LptKMT2C/DWDR82WDR5ASH2CXXC1SET1A/BDPY30RBBP5KMT2F/GMEN1WDR5ASH2MLL1/2DPY30RBBP5KMT2A/BHCF1PTIPWDR5ASH2MLL3/4DPY30RBBP5UTXPA1NCOA6KMT2C/DDrosophilaCOMPASSFamilyMammalianCOMPASSFamilyActivetranscriptionActivetranscription;cell-cycleregulation;WntsignalingTranscriptionalrepression;DNAdamageresponsePolycombsilencing;Xchromosomeinactivation;cellfatedeterminationWHSC1KMT3AKMT3AKMT3AKMT3BAF17ENLTRRAPAF10AF9DOT1Dot1GrappaKMT4KMT4KMT4KMT5B/CSUV4-20H1/H2KMT5B/CPR-Set7KMT5APR-Set7KMT5APclJarid2JingSu(z)12Esc/EsclNurf55E(z)MTF2JARID2AEBP2SUZ12EEDRBBP4/RBBP7EZH1/EZH2PHF19PHF1KMT6KMT6DotComNotdetectedCH3CH3CH3Monomethylation(me)Dimethylation(me2)Trimethylation(me3)NotdetectedNotdetectedMes-4Set2RNAPolIICTDSet2RNAPolIICTDSET2RNAPolIICTDS-adenosyl-L-methionineKMTS-adenosyl-L-methionineKMTS-adenosyl-L-methionineKMTYeastS.cerevisiae)Su(var)3-9NotdetectedSu(var)4-20CH3CH3CH3SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifardStowersInstituteforMedicalResearch,KansasCity,MO64110,USA498Cell149,April13,2012©2012ElsevierInc.DOI10.1016/j.cell.2012.03.025Seeonlineversionforlegendandreferences.498.e1Cell149,April13,2012©2012ElsevierInc.DOI10.1016/j.cell.2012.03.025SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifardStowersInstituteforMedicalResearch,KansasCity,MO64110,USALysinemethyltransferases(KMTs)catalyzethetransferofone,two,orthreemethylgroupsfromS-adenosyl-L-methionine(SAM)totheε-aminogroupofalysineresidueonahistonetogeneratemono-,di-,andtrimethylate...
