ResourceLiveTrackingofInter-organCommunicationbyEndogenousExosomesInVivoGraphicalAbstractHighlightsdSingleendogenousEVscanbelive-visualizedinthezebrafishembryowithCD63-pHluorindSynteninintheYSLregulatesexosomereleaseintothebloodforfurtherdisseminationdYSLexosomesaretakenupbymacrophagesandendothelialcellsinthetailoftheembryodUptakeisscavengerreceptor-anddynamin-dependentandprovidestrophicsupportAuthorsFrederikJ.Verweij,CelineRevenu,GuillaumeArras,...,FilippoDelBene,Grac¸aRaposo,GuillaumevanNielCorrespondencefrederik.verweij@inserm.fr(F.J.V.),guillaume.van-niel@inserm.fr(G.v.N.)InBriefVerweijetal.developaninvivomodelusingzebrafishembryostolive-tracktheproduction,journey,andfateofindividualexosomes.Usingacombinationofimagingmethodsandproteomicanalysis,theyinvestigatethecompositionofendogenousexosomesandthemolecularmechanismscontrollingtheirbiogenesis,fates,andfunctionsinreceivingcells.Verweijetal.,2019,DevelopmentalCell48,573–589February25,2019ª2019ElsevierInc.https://doi.org/10.1016/j.devcel.2019.01.004DevelopmentalCellResourceLiveTrackingofInter-organCommunicationbyEndogenousExosomesInVivoFrederikJ.Verweij,1,2,*CelineRevenu,3GuillaumeArras,4FlorentDingli,4DamarysLoew,4D.MichielPegtel,5GautierFollain,6GuillaumeAllio,6JackyG.Goetz,6PascaleZimmermann,7PhilippeHerbomel,8FilippoDelBene,3Grac¸aRaposo,1andGuillaumevanNiel1,2,9,*1InstitutCurie,PSLResearchUniversity,CNRSUMR144,Paris75005,France2InstituteforPsychiatryandNeuroscienceParis,HopitalSaint-Anne,Universite´Descartes,INSERMU894,Paris75014,France3InstitutCurie,PSLResearchUniversity,INSERMU934,CNRSUMR3215,SorbonneUniversite´,Paris75005,France4InstitutCurie,PSLResearchUniversity,CentredeRecherche,LaboratoiredeSpectrome´triedeMasseProte´omique,Paris,France5DepartmentofPathology,CancerCenterAmsterdam,theNetherlands6INSERMUMR_S1109,Universite´deStrasbourg,Fe´de´rationdeMe´decineTranslationnelledeStrasbourg,Strasbourg,France7CentredeRechercheenCance´rologiedeMarseille,Aix-MarseilleUniversite´,Marseille13284,...
