ArticleSTINGSensesMicrobialViabilitytoOrchestrateStress-MediatedAutophagyoftheEndoplasmicReticulumGraphicalAbstractHighlightsdLiveGram-positivebacteriacauseERstress,mTORC1inactivation,andER-phagydER-phagycontrolstheaugmentedinterferonresponsetoliveGram-positivebacteriadER-phagyresolvesERstressandrescuesphagocytesfromdeathuponinfectiondSTINGsensesc-di-AMPasavita-PAMPtodriveER-phagyandinterferonproductionAuthorsJulienMoretti,SoumitRoy,DominiqueBozec,...,GarabetYeretssian,DouglasR.Green,J.MagarianBlanderCorrespondencejmblander@med.cornell.eduInBriefDetectionoflivebacteriathroughSTINGtriggersER-phagyandresolutionofcellularstress,allowingcellstodealwiththethreatandremainviableandfunctional.Morettietal.,2017,Cell171,809–823November2,2017ª2017ElsevierInc.https://doi.org/10.1016/j.cell.2017.09.034ArticleSTINGSensesMicrobialViabilitytoOrchestrateStress-MediatedAutophagyoftheEndoplasmicReticulumJulienMoretti,1,2SoumitRoy,14,15DominiqueBozec,6JenniferMartinez,7JessicaR.Chapman,8BeatrixUeberheide,8DudleyW.Lamming,9ZhijianJ.Chen,10TiffanyHorng,11GarabetYeretssian,12DouglasR.Green,13andJ.MagarianBlander1,2,3,4,5,16,*1TheJillRobertsInstituteforResearchinInflammatoryBowelDisease2JoanandSanfordI.WeillDepartmentofMedicine3DepartmentofMicrobiologyandImmunology4SandraandEdwardMeyerCancerCenter5ImmunologyandMicrobialPathogenesisProgram,WeillCornellGraduateSchoolofMedicalSciencesWeillCornellMedicine,CornellUniversity,NewYork,NY10021,USA6BrainTumorNanotechnologyLaboratory,DepartmentofNeurosurgery,TischCancerInstitute,TheIcahnSchoolofMedicineatMountSinai,NewYork,NY10029,USA7Immunity,Inflammation,andDiseaseLaboratory,InflammationandAutoimmunityGroup,NationalInstituteofEnvironmentalHealthSciences,ResearchTrianglePark,NC27709,USA8OfficeofCollaborativeScience,DepartmentofBiochemistryandMolecularPharmacology,NewYorkUniversitySchoolofMedicine,NewYork,NY10016,USA9DepartmentofMedicine,UniversityofWisconsin-Madison,Madison,WI53705,USA10DepartmentofMolecularBiologyandHowardHughesMedicalInstitut...
