ArticleExosome-TransmittedlncARSRPromotesSunitinibResistanceinRenalCancerbyActingasaCompetingEndogenousRNAGraphicalAbstractHighlightsdlncARSRpromotessunitinibresistanceandpredictspoorresponseofRCCpatientsdIntercellulartransferoflncARSRbyexosomesdisseminatessunitinibresistancedlncARSRactsasaceRNAformiR-34andmiR-449topromoteAXLandc-METexpressiondTargetinglncARSRorAXL/c-METinsunitinib-resistantRCCrestoresdrugsensitivityAuthorsLeQu,JinDing,ChengChen,...,Ying-HaoSun,Hong-YangWang,Lin-HuiWangCorrespondencehywangk@vip.sina.com(H.-Y.W.),wanglinhuicz@163.com(L.-H.W.)InBriefQuetal.identifylncARSRasamediatorofsunitinibresistanceinrenalcellcarcinomabyactingasacompetingendogenousRNAformiR-34andmiR-449,therebyincreasingexpressionoftheirtargetsAXLandc-MET,andshowthatexosome-mediatedtransmissionoflncARSRcanconferresistancetosensitivecells.AccessionNumbersGSE69535Quetal.,2016,CancerCell29,653–668May9,2016ª2016ElsevierInc.http://dx.doi.org/10.1016/j.ccell.2016.03.004CancerCellArticleExosome-TransmittedlncARSRPromotesSunitinibResistanceinRenalCancerbyActingasaCompetingEndogenousRNALeQu,1,10JinDing,2,10ChengChen,2,3,10Zhen-JieWu,1,10BingLiu,1,10YiGao,1WeiChen,1FengLiu,4WenSun,2Xiao-FengLi,2XueWang,2YueWang,5Zhen-YuXu,5LiGao,6QingYang,7BinXu,7Yao-MingLi,7Zi-YuFang,7Zhi-PengXu,1YiBao,1Deng-ShuangWu,1XiongMiao,8Hai-YangSun,9Ying-HaoSun,7Hong-YangWang,2,*andLin-HuiWang1,*1DepartmentofUrology,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai200003,China2TheInternationalCooperationLaboratoryonSignalTransduction,EasternHepatobiliarySurgeryHospital,SecondMilitaryMedicalUniversity,Shanghai200433,China3DepartmentofMedicalOncology,JinlingHospital,NanjingUniversityClinicalSchoolofMedicine,Nanjing210002,China4DepartmentofMedicalGenetics5DepartmentofHistologyandEmbryologyCollegeofBasicMedicine,SecondMilitaryMedicalUniversity,Shanghai200433,China6DepartmentofPathology7DepartmentofUrology8DepartmentofOrthopedicsChanghaiHospital,SecondMilitaryMedicalUniversity,Shanghai200433,China9Depart...
