CellSignalingTechnology©2003–2017CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyInflammasomeSignalingIκBαIκBαp65/RelANF-κBp65/RelANF-κBpro-caspase-1pro-caspase-1pro-mCasp-11/pro-hCasp-4,5mCasp-11/hCasp-4,5pro-caspase-1pro-caspase-1caspase-1P2X7TNFRTLR4TNF-αLPSIKKβIKKαTRAFNEK7lysosomaldamageASCNLRP3NLRP1NLRC4NAIPsASCAIM2ASCASCNLRP3TRIFNEMOMyD88K+effluxCathepsinsautophagyCrystalineSubstances(alum,uricacid,silica)CholesterolCrystalsAmyloid-βPAMPs/DAMPspore-formingtoxinsvirus,bacteria,fungipro-IL-1βNLRP3inflammasomecomplexInflammasomeComplexpro-IL-18IL-1βIL-18inflammationROSLPSATPdsDNAAnthraxtoxinFlagellinTypeIIIsecretionsystemNoncanonicalGram-negativebacteriainflammasomeactivatorsareindicatedingreenSignal1Signal2NucleusMitochondria•mtDNA•mtROS•NLRP3localization•cardiolipinTXNIPCa2+NLRP3inflammasomeGasderminDcleavageGasderminNOX2phagosomematurationglycolyticenzymesmetabolismeicosanoidsynthesisvasodilationhemoconcentrationpyroptosispyroptosiscleavage
