Ferroptosis:aregulatedcelldeathnexuslinkingmetabolism,redoxbiology,anddiseaseBrentR.Stockwell1,2,JosePedroFriedmannAngeli3,HülyaBayir4,AshleyI.Bush5,MarcusConrad3,ScottDixon6,SimoneFulda7,SergioGascon8,26,StavroulaK.Hatzios9,ValerianKagan10,KayNoel11,XuejunJiang12,AndreasLinkermann13,MaureenE.Murphy14,MichaelOverholtzer12,AtsushiOyagi15,GabrielaPagnussat16,JasonPark17,QitaoRan18,CraigS.Rosenfeld11,KonstantinSalnikow19,DaolinTang20,FrankTorti21,SuzyTorti22,ShinyaToyokuni23,K.A.Woerpel24,andDonnaD.Zhang251DepartmentofBiologicalSciences,ColumbiaUniversity,550West120thStreet,MC4846,NewYork,NY10027USA2DepartmentofChemistry,ColumbiaUniversity,550West120thStreet,MC4846,NewYork,NY10027USA3InstituteofDevelopmentalGenetics,HelmholtzZentrumMünchen,DeutschesForschungszentrumfürGesundheitundUmwelt(GmbH),München,Germany4DepartmentofCriticalCareMedicine,SafarCenterforResuscitationResearchandCenterforFreeRadicalandAntioxidantHealth,UniversityofPittsburgh,Pittsburgh,PAUSA5TheFloreyInstituteofNeuroscienceandMentalHealth,TheUniversityofMelbourne,Parkville,VICAustralia6DepartmentofBiology,StanfordUniversity,Stanford,CAUSA7InstituteforExperimentalCancerResearchinPediatrics,Goethe-UniversityFrankfurt;GermanCancerConsortium(DKTK),partnersiteFrankfurt;GermanCancerResearchCenter(DKFZ),Heidelberg,Germany8Ludwig-MaximiliansUniversityofMunich,PhysiologicalGenomics,BiomedicalCenter(BMC),Planegg-Martinsried,Germany9DepartmentofMolecular,CellularandDevelopmentalBiology,YaleUniversity,NewHaven,CT06511,USA,andMicrobialSciencesInstitute,YaleUniversity,WestHaven,CT06516,USA10CenterforFreeRadicalandAntioxidantHealth,DepartmentsofEnvironmentalHealth,PharmacologyandChemicalBiology,Chemistry,RadiationOncology,UniversityofPittsburgh,Pittsburgh,PAUSA11CollaborativeMedicinalDevelopment,LLC,SausalitoCAUSACorrespondenceto:BrentR.Stockwell.Publisher'sDisclaimer:ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Them...
