SnapShot:HIV-1ProteinsChadM.SwansonandMichaelH.MalimDepartmentofInfectiousDiseases,King’sCollegeLondonSchoolofMedicine,LondonSE19RT,UKVirusProtein#copies/VirionInteractionswithOtherViralFactorsVirusProteinFunctioncellularPartnerscellularPartnerFunctions;ResultsofInteractionwithViralProteinsMatrix,MA(p17Gag)~5000Transmembraneglycoprotein(TM)PlasmamembranetargetingofGagforvirionassembly;Envincorporation;post-entryeventsPhosphatidylinositol(PI)4,5-bisphosphate[PI(4,5)P2]MediatesGaginteractionwithplasmamembraneTIP47PromotesEnvincorporationintovirionsCapsid,CA(p24Gag)~5000(seeBriggsetal.,2004)VirioncorestructureandassemblyCyclophilinAModulatessensitivitytoTRIM5α;suppressedbycyclosporinATRIM5αPost-entryinhibitorofinfectionNucleocapsid,NC(p7Gag)~5000RNAgenome(gRNA)ofvirusVirionpackagingofgenomeRNA;RNAchaperone;virionassemblyHP68/ABCE1PromotesvirionassemblyAPOBEC3G,APOBEC3FPackagedintovirionswithRNA;inhibitsinfection;G-to-AhypermutationtRNALys3Primerforreversetranscription7SLRNA,othercellularRNAsUnknownp6Gag~5000VprPromotesvirionbuddingTSG101RecruitESCRTmachinerytopromotevirionbuddingALIXProtease,PR~250Gag,PolProteolyticprocessingofGagandGag-PolpolyproteinsPRmaycleavemanycellularproteinsReverseTranscriptase,RT~250gRNA,INcDNAsynthesis;RNaseHdomaindegradesRNAtRNALys3PrimerforreversetranscriptionIntegrase,IN~250ViralcDNA,RTCovalentinsertionofviruscDNAintocellularDNALEDGF/p75cDNAintegration;targetingtoactivegenesINI1Virionassembly;reversetranscription/integrationUNG2DNArepairenzyme;enhancesreplicationfidelitySurfaceGlycoprotein,SU(gp120Env)4to35trimersTMBindscell-surfacereceptors;mediatesvirusattachmentandentryCD4CD4plusCCR5/CXCR4mediatevirionentry;majordeterminantsofviraltropismChemokinereceptors(CCR5andCXCR4)C-typelectinreceptors(DC-SIGN,Langerin)Virioncapture;viraltransmissionfromdendriticcellstoTcellsTransmembraneGlycoprotein,TM(gp41Env)4to35trimersSU,MAContainsfusionpeptide;mediatesmembranefusionandvirusentryTIP47EnvincorporationintovirionsClathrinsortingmachinery(AP...
