ArticlePEBP1WardensFerroptosisbyEnablingLipoxygenaseGenerationofLipidDeathSignalsGraphicalAbstractHighlightsdAnewpro-ferroptoticroleforanoldactor,PEBP1—catalyticreshuffleof15LOdEpithelialredoxphospholipoxysomeoxidizesunsaturatedphosphatidylethanolaminesdPEBP1andGPX4aremasterregulatorsofferroptosisindiverseepithelialcellsdPEBP1/15LO-drivenferroptosisoccursinasthma,kidneyinjury,andbraintraumaAuthorsSallyE.Wenzel,YuliaY.Tyurina,JinmingZhao,...,IvetBahar,Hu¨lyaBayır,ValerianE.KaganCorrespondencewenzelse@upmc.edu(S.E.W.),bayihx@ccm.upmc.edu(H.B.),kagan@pitt.edu(V.E.K.)InBriefThesmallscaffoldingproteinPEBP1regulatesferroptoticcelldeathbybindingwithlipoxygenasesandallowingthemtogeneratelipidperoxides.Wenzeletal.,2017,Cell171,628–641October19,2017ª2017ElsevierInc.https://doi.org/10.1016/j.cell.2017.09.044ArticlePEBP1WardensFerroptosisbyEnablingLipoxygenaseGenerationofLipidDeathSignalsSallyE.Wenzel,1,2,*YuliaY.Tyurina,3JinmingZhao,1ClaudetteM.St.Croix,4HaiderH.Dar,3GaoweiMao,5VladimirA.Tyurin,3TamilS.Anthonymuthu,5AlexandrA.Kapralov,3AndrewA.Amoscato,3KarolinaMikulska-Ruminska,6,12IndiraH.Shrivastava,3,6ElizabethM.Kenny,5QinYang,5JoelC.Rosenbaum,7LouisJ.Sparvero,3DavidR.Emlet,5XiaoyanWen,5YoshinoriMinami,1FengQu,3SimonC.Watkins,4TheodoreR.Holman,11AndrewP.VanDemark,7JohnA.Kellum,5IvetBahar,6Hu¨lyaBayır,3,5,13,*andValerianE.Kagan3,8,9,10,14,*1DepartmentofMedicine2DepartmentofImmunology3DepartmentofEnvironmentalandOccupationalHealth,CenterforFreeRadicalandAntioxidantHealth4DepartmentofCellBiology5DepartmentofCriticalCareMedicine,CenterforCriticalCareNephrology,SafarCenterforResuscitationResearch6DepartmentofComputationalandSystemBiology7DepartmentofBiologicalSciences8DepartmentofChemistry9DepartmentofPharmacologyandChemicalBiology10DepartmentofRadiationOncologyUniversityofPittsburgh,Pittsburgh,PA,USA11DepartmentofChemistryandBiochemistry,UniversityofCalifornia,SantaCruz,CA,USA12InstituteofPhysics,NicolausCopernicusUniversity,Torun,Poland13Children’sHospitalofPittsbu...
