CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyHippoSignalingZO-2AMOTAMOTAMOTWBP2β-TrCPFRMDMerlinKIBRASAV114-3-3MARK4α-cateninp73RUNXMst1/2SIK1-3CK1RhoLKB1LATS1/2MOB1F-actinITCHVGL4AjubaYAP/TAZYAP/TAZYAP14-3-3YAPTEAD1-4TEAD1-4SmadRASSFTAOK-1-3PP2APP1ASPP2MerlinGα12/13Gαq/11Gαi/oGαsFAT4???CD44CrbTranscriptionNucleusCytoplasmAdherensJunctionTightJunctionGPCRSignalingMechanicalSignalingYAP/TAZYAP/TAZYAP/TAZYAP/TAZYAP/TAZ
