HIF2�specificCyclinD1Cell-cycleprogressionSod2,CatalaseRedoxhomeostasisTGF�ProliferationEPOErythropoiesisKidney,liverMMP13CartilagedestructionChondrocyteDLL4NotchVascularremodelingEndothelialcellOCT4PluripotencyEmbryonicstemcellArginase1NOMacrophageIRS2InsulinsensitivityLiver?PexophagyLiverVE-PTPAdherensjunctionintegrity,endothelialbarrierEndothelialcellHIF1�specificBNIP3,BNIP3LAutophagyLOX,PLOD2LDHA,PDK1,PGK1GlycolysisREDD1mTORGrowthcontrolROR�tIL17Th17celldevelopmentCD4+TcelliNOSNOMyeloidcell,adipocyteWnt,NotchStemness,differentiationStemcell,progenitorcellCRAMP(LL37)AntimicrobialactionMyeloidcell,intestinalepitheliumSF3B1KHK-CFructolysisHeartCriptoGRP78Glycolysis,quiescenceHematopoieticstemcellHIF1�ARNTHypoxiaNormoxiaHREHIF2�HREPHDFIHp300/CBPp300/CBPp300/CBPSuccinateFumarateO2O22-OxoglutarateFe2+AscorbateROSFBP1COMMD1miR-107PKM2mTORC1PCAFSiah2XBP1IFN��-cateninNF�BmTORC2SENP1Meis1SIRT1IL4SIRT1SIRT6GSK3�ER�CITED2p53miR-210TargetFunctionContextspecificityARNTPAS-BPAS-BPAS-AbHLHHIF2�-ARNTheterodimeroffandonDNAbHLH�1�2�2�1Small-moleculebindingpocketsProflavinesite0X3siteIRP1IFN�miR-30c-2-3pmiR-30a-3pProteasomaldegradationUbUbUbUbHIF�AsnProOHHOVHLARNTHIF2��1�2LHLHm�1PAS-APAS-APAS-BPAS-BPAS-AHIF1�/HIF2�commonGLUT1GlucosetransportVEGFAAngiogenesisCAIX,CAXIIpHhomeostasisCXCR4,SDF1Migration,adhesionTwistEpithelial-mesenchymaltransitionBCL2SurvivalFilaggrinSkinbarrierformationEpidermisPLIN2Lipidstorage,ERhomeostasisKidney,liver?SustainedeffectorresponseCD8+TcellIL1�Macrophage�2Seeonlineversionforlegendandreferences.1288Cell163,November19,2015©2015ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2015.11.011SnapShot:Hypoxia-InducibleFactorsKyoungEunLeeandM.CelesteSimonAbramsonFamilyCancerResearchInstitute,PerelmanSchoolofMedicineattheUniversityofPennsylvania,Philadelphia,PA19104,USA1288.e1Cell163,November19,2015©2015ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2015.11.011SnapShot:Hypoxia-InducibleFactorsKyoungEunLeeandM.CelesteSimonAbramsonFam...
