KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysSuFuGli1/2/3SuFuGli1/2/3SuFuPKACK1GSK-3ββ−TrCPGli1/2/3Gli3-RGli1/2/3Gli1/2-ActGli1/2-ActCyclinD,CyclinE,MycGli1,Patched,HIPHhNHhNHhSknDispatchedER/GolgiHhSecretingCellPTCH1NucleusGli1/2notranscriptionoftargetgenesNucleusCytoplasmCytoplasmActiveRepressorSmoSmoProteasomePrimaryCiliumPrimaryCiliumOn-StateOff-StateCDO/BOC(Ihog/boi)ShhKCTD11β-ArrestinDhhIhhMammalianLigands:PTCH1CDO/BOC(Ihog/boi)MicrotubulesMicrotubulesGli3-RCOS2/Kif7COS2/Kif7HhNGαiHedgehogSignaling©2006–2014CellSignalingTechnology,Inc.
