Seeonlineversionforforlegendandreferences.458Cell159,October9,2014©2014ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2014.09.037SnapShot:HistoneModificationsHeHuang,1BenjaminR.Sabari,2BenjaminA.Garcia,3C.DavidAllis,2andYingmingZhao11BenMayDepartmentofCancerResearch,TheUniversityofChicago,Chicago,IL60637,USA2LaboratoryofChromatinBiologyandEpigenetics,TheRockefellerUniversity,NewYork,NY10021,USA3DepartmentofBiochemistryandBiophysics,UniversityofPennsylvania,Philadelphia,PA19104,USABoxesindicateglobulardomainMeAcPrBuCrHibMaSuUbFoCitPhOHOgArMethylation(K,R)Acetylation(K,S,T)Propionylation(K)Butyrylation(K)Crotonylation(K)2-Hydroxyisobutyrylation(K)Malonylation(K)Succinylation(K)Ubiquitination(K)Formylation(K)Citrullination(R)Phosphorylation(S,T,Y,H)Hydroxylation(Y)O-GlcNAcylation(S,T)ADPribosylation(K,E)H31020304055627880106114121127130+H3N-AQAGGAPQLAAAAPAGGVPHPGV…QT…IL…FDLFQSS…DN…AR…PD…ARIRGERA-COO-PhMeCitPhMeAcCrHibPhMeCitMeAcBuCrHibAcPhOgMe/Ac/BuHib/Su/UbMeCitMe/Ac/Bu/CrHib/Ub/FoAcMe/Ac/Pr/Bu/CrHib/Su/Ub/FoMeCitAcPhMeAcHibUbMeAcArMePhMePhPhMe/Ac/Pr/Cr/HibSu/Ma/Ub/FoMeMeAcHibFoMe/Ac/Bu/CrHib/Su/Ub/ArAcPhMePhPhAcBuMe/Ac/Bu/CrHib/Su/Fo/UbMeOgMe/Ac/Bu/CrHib/Su/Ub/FoH4MeCitPhMeCitMe/Ac/PrBu/Cr/HibAc/Pr/BuCr/HibMe/Ac/Pr/BuCr/Hib/Su/FoMe/Ac/Pr/BuCr/Hib/ArMeCitMeAcMeMe/Ac/Pr/BuHib/Su/Ub/FoMePrBuHibPhOgPhOHMeMeCrHibUbFoMeMeMeMe/Ac/Pr/Bu/CrHib/Su/Ub/FoMe/Ac/Pr/BuHib/Su/FoPhOHAc/Pr/Bu/CrHib/Su/Ub/FoPhPhPhAcHN-GGGGGLGGGAVLDNIQGITPAIR…VRIGLIEETGVLV…VIDAVTYTEATVTAMDVVALSRKKKKRHRKRKRKSYRKRHKRKYKRQGRTLYGFGG-COO-10203043506065708090100H2AAcHN-SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERV...PVYL…LTA…ARDNKKT…IRNDEELNKLLGKVTI…LLPKKTESHHKAKGK-COO-1020304048505870879060100115120PhMeCitAcBuHibMeAcHibSuMeAcUbArAcUbMeAc/Cr/HibSu/Ub/FoOHMePhPhMeMeAcHibHibMeMe/Ac/Pr/Bu/CrHib/Su/Ub/FoMePhOgCrUbPhMe/Ac/CrHib/Ub/FoPhMePrCrUbAcAcH2B+H3N-PEPAKSA…PKKGSKKAVTKAQKKD…RKRSRKESYS…YKVLK...TGISSK...S...SEASRLAHYNKRSTITSRE…VRL…AKH…GTKAVTKYTSAK-COO-1020293042526475809098107114120100ArPh...
