REVIEWGutmicrobesincardiovasculardiseasesandtheirpotentialtherapeuticapplicationsLingJin1,XiaomingShi2,JingYang2,YangyuZhao2,LixiangXue1&,LiXu3&,JunCai4&1CenterofBasicMedicalResearch,InstituteofMedicalInnovationandResearch,PekingUniversityThirdHospital,Beijing100191,China2DepartmentofObstetricsandGynecology,PekingUniversityThirdHospital,Beijing100191,China3HeartCenterandBeijingKeyLaboratoryofHypertension,BeijingChaoyangHospital,CapitalMedicalUniversity,Beijing100043,China4HypertensioncenterofFuwaiHospital,StateKeyLaboratoryofCardiovascularDisease,NationalCenterforCardiovascularDiseases,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100037,China&Correspondence:lixiangxue@hsc.pku.edu.cn(L.Xue),imxuli@hotmail.com(L.Xu),caijun@fuwaihospital.org(J.Cai)ReceivedMay5,2020AcceptedAugust19,2020ABSTRACTMicrobialecosystemcomprisesacomplexcommunityinwhichbacteriainteractwitheachother.Thepotentialrolesoftheintestinalmicrobiomeplayinhumanhealthhavegainedconsiderableattention.Theimbalanceofgutmicrobialcommunityhasbeenlookedtomultiplechronicdiseases.Cardiovasculardiseases(CVDs)areleadingcausesofmorbidityworldwideandareinflu-encedbygeneticandenvironmentalfactors.RecentadvanceshaveprovidedscientificevidencethatCVDmayalsobeattributedtogutmicrobiome.Inthisreview,wehighlightthecomplexinterplaybetweenmicrobes,theirmetabolites,andthepotentialinfluenceonthegenerationanddevelopmentofCVDs.ThetherapeuticpotentialofusingintestinalmicrobiomestotreatCVDisalsodiscussed.ItisquitepossiblethatgutmicrobesmaybeusedforclinicaltreatmentsofCVDinthenearfuture.KEYWORDSgutmicrobiota,cardiovasculardiseases,actionmechanism,therapeuticapplicationsINTRODUCTIONCardiovasculardiseases(CVDs)havetakencenterstageastheleadingcausesofmorbidityandmortalityworld-wide.ThecauseofCVDisstillunderinvestigation,butthoughttobeinfluencedbygeneticandenvironmentalfactors.RecentstudieshaveshedlightonthepotentialrolesoftheintestinalmicrobiomeinCVD.Microbesintheintestinevastlyoutnumberthetotalnumberofhumancells....
