PI(3,5)P2PI(3,4)P2PI(4,5)P2PI(3,4,5)P3PI(5)PPI(3)PSphingosineSphingosine1-PCeramideCeramide1-PDAGMAGLPAPAPI(4)PPIMTM1,MTMR1,MTMR2,MTMR3,MTMR6,MTMR8,MTMR14,PTEN,TPTE2PPAP2A,PPAP2B,PPAP2C,PPAPDC1A,PPAPDC1B,PPAPDC2,LPIN1,LPIN2,LPIN3PIK3CA,PIK3CB,PIK3CD,PIK3CG,IPMK,PIK3C2A,PIK3C2BPIK3C3,PIK3C2A,PIK3C2B,PIK3C2G,PIK3CA,PIK3CB,PIK3CD,PIK3CGPIK3C2A,PIK3C2B,PIK3C2G,PIK3CA,PIK3CB,PIK3CD,PIK3CGDGKA,DGKB,DGKG,DGKD,DGKE,DGKZ,DGKH,DGKQ,DGKI,DGKK,EIF2AK3,AGKTPTE2,FIG4,OCRL,INPP5B,INPP5D,INPP5E,INPP5F,INPP5J,INPP5K,INPPL1,SYNJ1,SYNJ2SGPP1,PPAP2A,PPAP2B,PPAP2CPPAP2A,PPAP2B,PPAP2CMTM1,MTMR1,MTMR2,MTMR3,MTMR4,MTMR6,MTMR7,MTMR8,MTMR14,PTEN,TPTE2,SACM1L,SYNJ1PIP4K2A,PIP4K2B,PIP4K2CPI4K2A,PI4K2B,PI4KA,PI4KBPIKFYVEPIP5K1APIP5K1BPIP5K1CPIP4K2APIP5K1APIP5K1BPIP5K1CPIKFYVEPIP5K1APIP5K1BFIG4INPP5EPIP5K1APIP5K1BPIP5K1CPIP5K1APIP5K1BPIP5K1CTMEM55A,TMEM55BPPAP2A,PPAP2B,PPAP2CSACM1L,SYNJ1SPHK1,SPHK2INPP4A,INPP4BPTEN,TPTE2PTEN,TPTE2PTPMT1CERKPIP4K2BAGKTPTE2,FIG4,OCRL,INPP5B,INPP5D,INPP5E,INPP5F,INPP5J,INPP5K,INPPL1Seeonlineversionforlegendandreferences.376Cell156,January16,2014©2014ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2014.01.003SnapShot:LipidKinaseandPhosphataseReactionPathwaysSimonA.RudgeandMichaelJ.O.WakelamTheBabrahamInstitute,BabrahamResearchCampus,CambridgeCB223AT,UK376.e1Cell156,January16,2014©2014ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2014.01.003SnapShot:LipidKinaseandPhosphataseReactionPathwaysSimonA.RudgeandMichaelJ.O.WakelamTheBabrahamInstitute,BabrahamResearchCampus,CambridgeCB223AT,UKThisSnapShotpresentsthereactionpathwayscatalyzedbytheknownmammalianenzymes—listedintheSnapShot“LipidKinasesandPhosphatases”(Cell155,December19,2013)—thateitherphosphorylateordephosphorylatelipids.Incasesinwhichonlyinvitrodatahavebeenreported,thegeneencodingtheenzymeisshowninitalicsand/oradashedlineisusedtorepresentthereactioncatalyzed.ThelipidfattyacidmoietiesdepictedinthereactionpathwaysinthisSnapShothavebeenpurposelysimplified,andthereforetheydonotrepresentthecomplexityofwhatoccursnaturally,i.e.,fattyacidscanvaryinbothlengthandsaturation,inparticular,thepolyphosphoinositidesgenerallyhaveapolyunsaturatedfattyacidmoietyatthesn-2position.ABBREVIATIONSPI,phosphatidylinositol;PI(3)P,phosphatidylinositol3-phosphate;PI(4)P,phosphatidylinositol4-phosphate;PI(5)P,phosphatidylinositol5-phosphate;PI(3,4)P2,phosphatidylinositol3,4-bisphosphate;PI(3,5)P2,phosphatidylinositol3,5-bisphosphate;PI(4,5)P2,phosphatidylinositol4,5-bisphosphate;PI(3,4,5)P3,phosphatidylinositol3,4,5-trisphosphate;PA,phosphatidicacid;LPA,lysophosphatidicacid;DAG,diacylglycerol;MAG,monoacylglycerol.AckNOwlEdgmENTSWorkintheS.A.R.andM.J.O.W.labissupportedbytheBiotechnologyandBiologicalSciencesResearchCouncil.
