ContentslistsavailableatScienceDirectSeminarsinCancerBiologyjournalhomepage:www.elsevier.com/locate/semcancerReviewFerroptosisisatypeofautophagy-dependentcelldeathBorongZhoua,⁎,JiaoLiua,RuiKangb,DanielJ.Klionskyc,GuidoKroemerd,e,f,g,h,i,j,DaolinTangb,⁎aTheThirdAffiliatedHospital,GuangzhouMedicalUniversity,Guangzhou,Guangdong,510150,ChinabDepartmentofSurgery,UTSouthwesternMedicalCenter,Dallas,TX,75390,USAcLifeSciencesInstituteandDepartmentofMolecular,CellularandDevelopmentalBiology,UniversityofMichigan,AnnArbor,MI,48109,USAdUniversitéParisDescartes,SorbonneParisCité,75006Paris,FranceeEquipe11labelliséeLigueNationalecontreleCancer,CentredeRecherchedesCordeliers,75006Paris,FrancefInstitutNationaldelaSantéetdelaRechercheMédicale,U1138,Paris,FrancegUniversitéPierreetMarieCurie,75006Paris,FrancehMetabolomicsandCellBiologyPlatforms,GustaveRoussyCancerCampus,94800Villejuif,FranceiPôledeBiologie,HôpitalEuropéenGeorgesPompidou,AP-HP,75015Paris,FrancejDepartmentofWomen'sandChildren'sHealth,KarolinskaUniversityHospital,17176Stockholm,SwedenARTICLEINFOKeywords:AutophagyFerroptosisIronLipidperoxidationCelldeathABSTRACTMacroautophagy(hereafterreferredtoasautophagy)involvesanintracellulardegradationandrecyclingsystemthat,inacontext-dependentmanner,caneitherpromotecellsurvivaloracceleratecellulardemise.Ferroptosiswasoriginallydefinedin2012asaniron-dependentformofcancercelldeathdifferentfromapoptosis,necrosis,andautophagy.However,thislatterassumptioncameintoquestionbecause,inresponsetoferroptosisactivators(e.g.,erastinandRSL3),autophagosomesaccumulate,andbecausecomponentsoftheautophagymachinery(e.g.,ATG3,ATG5,ATG4B,ATG7,ATG13,andBECN1)contributetoferroptoticcelldeath.Inparticular,NCOA4-facilitatedferritinophagy,RAB7A-dependentlipophagy,BECN1-mediatedsystemxc−inhibition,STAT3-inducedlysosomalmembranepermeabilization,andHSP90-associatedchaperone-mediatedautophagycanpromoteferroptosis.Inthisreview,wesummarizecurrentknowledgeonthesignalingpathwaysinvolvedinferroptosis,whil...
