HumanGeneSymbol(Localization)PotentiallyRegulatedbyPotentiallyRegulatesCellularandDevelopmentalRolesMutantMousePhenotypeRoleinCancer/HumanDiseaseFOXJ1(17q25.1)FOXD1,bleomycinIFNG,IL2,NFKBIB,NFkB,protein-DNAT-lymphocyteproliferation.Randomdeterminationofleft-rightasymmetry,nocilia,growthfailure,hydrocephalus.Dieperinatally.FOXJ2(12p13.31)FOXJ3(1p34.1)FOXK1(7p22.1)Regulatescellcycleprogressioninmyogenicprogenitorcells.Atrophicskeletalmuscles,impairedsatellitecellfunction.FOXK2(17q25.3)FOXL1(16q24.1)2,4-dinitrophenol-ovalbuminconjugate,LPS,GLI1,TAC1,Hedgehogproteoglycan,SDC1,BMP2,BMP4Involvedinproteoglycanbio-synthesis.Gastricmucosahyperplasia,sup-pressedgastricacidsecretion.MesenchymalmodifierofAPC/Miningastro-intestinalcarcinogenesis.FOXL2(3q22.3)GDF9,INHBA,AMHGranulosacelldifferentiation;de-velopmentofovarianfollicle.Eyelidandforeheaddysmorphology;gonadaldysgenesisorprematureovarianfailureinfemales.Highrateofperinatalmortality.AssociatedwithBlepha-rophimosis-Ptosis-Epi-canthusInversus(BPES);Prematureovarianfailure.FOXM1(12p13.33)GLI1,doxorubicin,NRAS,ful-vestrant,butyricacid,FGF7,CDKN1A,YY1,MSA,vitaminD3,TNFSF11,IL6,CDC2CDC25B,CENPA,AURKB,CCNA2,CCNF,CENPB,BIRC5,CCNB1,CDKN1A,ESR1,ADAM17,GLB1ControlsprogressionintoSphase;regulatesgenesrequiredformitoticentry;liverdevelopment.Reducedhepatoblastandcar-diomyocytemitosis,ventricularhypoplasia.Dieperinatally.Upregulatedinpancreaticcancer.FOXN1(17q11.2)WNT5B,WNT4,BMP4,NogginFAM57A,SERPINB1,GZMA,MREG,IL7,TRG,PPP1R16B,C19ORF28,CD274,IVLEpithelialcellproliferation;keratinocytedifferentiation;hairfollicleandthymusdevelopment.Hairless,abnormalthymusandTcelldevelopment.Prematuredeath.Associatedwithimmuno-deficiency,alopecia,naildystrophy.FOXN2(2p22-p16)Upregulationassociatedwithadvancedpapillaryserousovariancarcinomainhumans.FOXN3(14q24.3-q31)INSR,STK11,camptothecin,ER,MEN1InvolvedinG2/Mphaseofcellcycle.RecruitsSKIPtorepressgenesimportantfortumorigenesis.FOXN4(12q24.12)NEUROD4,NEUROD1,PROX1Neuronfatecommitment,ama-crineandho...
