CellSignalingTechnology©2003–2018CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationTranscriptionalInhibitoryModificationPathwayDiagramKeyPhospholipidSignalingPWDNAMethylationrev.06/14/18—H3K36me3—H3K4me0—5-HydroxyMethylcytosine—Methylcytosine—Cytosine—H3K9me3—H3K27AcetylKeyTSSTSSMaintenanceMethylationDuringDNAReplicationDenovoCytosineMethylationUHRF1CAF1DNMT1DMAP1PCNADNAMethylationUHRF1CAF1DNMT1HDAC2DMAP1PCNAActiveGeneNucleosomeDepletedRegionInactiveGeneInactiveGenesTFTFTFTET1/2/3HDAC1HDAC1DNMT3LDNMT3LDNMT3A/BDNMT3A/BMBD1MCAFSETDB1HP1MeCP2MBD1MBD2/4HDACMBD2/4NuRDComplexHDACMeCP2SUV39H1CoRESTSin3ATet-MediatedCytosineDemethylationCytosineBERDNMT5-Formylcytosine5-MethylcytosineTet1/2/3Tet1/2/3Tet1/2/35-HydroxyMethylcytosineTDG5-CarboxycytosineATPHeterochromatinEuchromatinTSSrev.06/14/18—H3K36me3—H3K4me0—5-HydroxyMethylcytosine—Methylcytosine—Cytosine—H3K9me3—H3K27AcetylKeyTSSTSSMaintenanceMethylationDuringDNAReplicationDenovoCytosineMethylationUHRF1CAF1DNMT1DMAP1PCNADNAMethylationUHRF1CAF1DNMT1HDAC2DMAP1PCNAActiveGeneNucleosomeDepletedRegionInactiveGeneInactiveGenesTFTFTFTET1/2/3HDAC1HDAC1DNMT3LDNMT3LDNMT3A/BDNMT3A/BMBD1MCAFSETDB1HP1MeCP2MBD1MBD2/4HDACMBD2/4NuRDComplexHDACMeCP2SUV39H1CoRESTSin3ATet-MediatedCytosineDemethylationCytosineBERDNMT5-Formylcytosine5-MethylcytosineTet1/2/3Tet1/2/3Tet1/2/35-HydroxyMethylcytosineTDG5-CarboxycytosineATPHeterochromatinEuchromatinTSSrev.06/14/18
