ArticleTheBRAFPseudogeneFunctionsasaCompetitiveEndogenousRNAandInducesLymphomaInVivoGraphicalAbstractHighlightsdTheBRAFpseudogenefunctionsasaceRNAforBRAFinhumansandmicedBraf-rs1overexpressionpromotesBcelllymphomainmicedSilencingofBRAFP1affectsMAPKsignalingandproliferationofhumancancercellsdGenomicgainsandaberrantexpressionofBRAFP1arefoundinvarioushumancancersAuthorsFlorianA.Karreth,MarkusReschke,...,RobertoChiarle,PierPaoloPandolfiCorrespondenceppandolf@bidmc.harvard.eduInBriefTheinvivoevidencefortheregulatoryactivityofpseudogeneshasbeenlacking,andtheirroleindiseaseprogressionhasbeencorrelative.ThisstudynowshowsthattransgenicexpressionoftheBRAFpseudogeneinducesamalignancyinmiceresemblinghumandiffuselargeBcelllymphoma,establishingitsoncogenicfunction.Karrethetal.,2015,Cell161,1–14April9,2015ª2015ElsevierInc.http://dx.doi.org/10.1016/j.cell.2015.02.043ArticleTheBRAFPseudogeneFunctionsasaCompetitiveEndogenousRNAandInducesLymphomaInVivoFlorianA.Karreth,1MarkusReschke,1AnnaRuocco,1ChristopherNg,1BjoernChapuy,2ValentineLe´opold,1MarcelaSjoberg,3ThomasM.Keane,3AkankshaVerma,4UgoAla,1YvonneTay,1,9DavidWu,5NinaSeitzer,1MartinDelCastilloVelasco-Herrera,3AnneBothmer,1JacquelineFung,1FernandaLangellotto,6ScottJ.Rodig,7OlivierElemento,4MargaretA.Shipp,2DavidJ.Adams,3RobertoChiarle,6,8andPierPaoloPandolfi1,*1CancerResearchInstitute,BethIsraelDeaconessCancerCenter,DepartmentofMedicineandPathology,BethIsraelDeaconessMedicalCenter,HarvardMedicalSchool,Boston,MA02215,USA2DepartmentofMedicalOncology,Dana-FarberCancerInstitute,Boston,MA02115,USA3ExperimentalCancerGenetics,WellcomeTrustSangerInstitute,WellcomeTrustGenomeCampus,HinxtonCB101HH,UK4DepartmentofPhysiologyandBiophysics,InstituteforComputationalBiomedicine,WeillCornellMedicalCollege,NewYork,NY10021,USA5MeyerCancerCenter,WeillCornellMedicalCollege,NewYork,NY10021,USA6DepartmentofPathology,Children’sHospitalandHarvardMedicalSchool,Boston,MA02115,USA7DepartmentofPathology,BrighamandWomen’sHospital,Boston,MA02115,USA8Depar...
