710MolecularCell58,May21,2015©2015ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.molcel.2015.05.002Seeonlineversionforlegendandreferences.SnapShot:KinaseInhibitorsIIJinhuaWang1,2andNathanaelS.Gray1,21DepartmentofCancerBiology,Dana-FarberCancerInstitute,Boston,MA02215,USA2DepartmentofBiologicalChemistry&MolecularPharmacology,HarvardMedicalSchool,Boston,MA02115,USAKinasenameToolcompoundIC50KnownofftargetsOthercompoundsCASnumberPubMedIDMAP2KTrametinibMAP2K1:0.92nM;MAP2K2:1.8nMPD0325901,PD184352871700-17-321523318MAP2K1Selumetinib14nM606143-52-617332304MAP2K5BIX021884.3nMERK5BIX021891094614-84-218834865MAP3K5MSC2032964A93nMCK1dTCASK101124381-43-621064192PAK4PF-37583091.3nMPAK1/5/6898044-15-020439741ABLBafetinib5.8nMLynImatinib,nilotinib859212-16-116105974ABLGNF-5220nMGNF-2778277-15-920072125ALKCH54248021.9nMGAK,LTKLDK378,AP26113,ASP3026,crizotinib,TAE6841256580-46-721575866BMXBMX-IN-18nMBTK1431525-23-323594111BTKAVL-292<0.5nMBMX,ITK,TEC,TXKIbrutinib1202757-89-823709115BTKCGI17461.9nM910232-84-721113169DDRDDR1-IN-1105nM1449685-96-423899692EGFRAfatinib0.4nMErbB2Gefitinib,lapatinib439081-18-218408761ErbB2CP-72471410nMLapatinib,AZD8931537705-08-117942920ErbB3TX-85-123nM1603845-32-425326665FAKPND-11861.5nMPF-562271,defactinib,TAE2261061353-68-120234191FGFRBGJ-398FGFR1:0.9nM;FGFR2:1.4nM;FGFR3:1.0nM;FGFR4:60nMVEGFR2AZD4547872511-34-721936542FLT3AC2204.2nMKIT,PDGFRA,PDGFRB,RET,andCSF1RMLN518950769-58-119654408FMSGW258060nMOSI-930,linifanib870483-87-716249345IGF1RNVP-AEW541150nMINSR,FLT3,FLT3,TEKOSI-906(non-ATPcompetitive),BMS-536924475489-16-815050915JAK2Ruxolitinib0.036nMJAK1CEP33779941678-49-522037378JAK3Tofacitinib1nMJAK1,JAK2477600-75-214593182KITImatinib100nMPDGFR,v-AblMasitinib152459-95-510910906LCKWH-4-0232nMSrcPP1,PP2837422-57-816884310METSGX-5234nMINCB28060,ARQ197(non-ATPcompetitive)1022150-57-719934279PDGFRCP-673451PDGFRa:10nM;PDGFRb:1nMc-Kit343787-29-115705896SRCAZD05302.7nMLCK,c-YES,Lyn,Fyn,FGR,BLK,v-Abl379231-04-619393585SYKP505-151nMFGR,MLK1GSK1431370261-96-3,1370...
