SnapShot:IntraflagellarTransportDouglasG.Cole1andWilliamJ.Snell21UniversityofIdaho,Moscow,Idaho,USA,2UTSouthwesternMedicalCenter,Dallas,TX,USA784Cell137,May15,2009©2009ElsevierInc.DOI10.1016/j.cell.2009.04.053Seeonlineversionforlegendandreferences.ProteinMutantorKnockdownPhenotype/InteractionsandfunctionsIfTParticlessubcomplexAIFT144(Cr),DYF-2(Ce),WDR19(Mm),OSEG6(Dm)Moderateciliogenesis(Cr,Ce);retrogradeIFTdefect(Cr,Ce)IFT140(Cr,Mm),CHE-11(Ce),OSEG3(Dm)Moderateciliogenesis(Cr,Mm,Ce,Dm);retrogradeIFTdefect(Cr,Ce)IFT139(Cr),ZK328.7(Ce),THM1(Mm),(absentinDm)Moderateciliogenesis(Cr,Mm);retrogradeIFTdefect(Cr)IFT122(Cr),DAF-10(Ce),WDR10(Mm),OSEG1(Dm)Moderateciliogenesis(Cr,Ce,Dm);retrogradeIFTdefect(Cr,Ce)IFT121(Cr),IFTA-1(Ce),WDR35(Mm),OSEG4(Dm)Moderateciliogenesis(Ce)/interactswithIFT43(Cr,Hs)IFT43(Cr,Mm),(absentinCe,Dm)InteractswithIFT121(Cr,Hs)subcomplexBIFT172(Cr,Mm),OSM-1(Ce,Dm)Strongciliogenesis(Cr,Mm,Ce)/interactswithEB1(Cr);turnaroundofIFTmachineryatdistaltip(Cr)IFT88(Cr),OSM-5(Ce),Polaris/Tg737(Mm),NOMPB(Dm)StrongciliogenesisandanterogradeIFTdefect(Cr,Ce,Mm,Dm)/interactswithIFT52(Cr),IFT46(Ce),Hsp40(Mm)IFT81(Cr,Ce),CDV-1R(Mm),(absentinDm)Moderateciliogenesis(Ce)/interactswithIFT74/72(Cr,Hs)IFT80(Cr),CHE-2(Ce),WDR56(Mm),OSEG5(Dm)Strongciliogenesis(Ce)IFT74/72(Cr),IFT74(Ce),CMG-1(Mm),(absentinDm)Moderateciliogenesis(Ce)/interactswithIFT81(Cr,Hs)IFT70/DYF-1(Cr),DYF-1(Ce,Dm),TTC30A/B(Mm)Moderateciliogenesis(Cr,Ce)/regulatesOSM-3-mediatedanterogradeIFT(Ce)IFT57(Cr,Dm),CHE-13(Ce),HIPPI(Mm)Moderateciliogenesiscausingshortenedcilia(Cr,Ce)/interactswithHuntingtin-interactingprotein(Mm),IFT20(Mm),Apoptin(Mm)IFT52/BLD1(Cr),OSM-6(Ce,Dm),NGD5(Mm)StrongciliogenesisandanterogradeIFTdefect(Cr,Ce)/interactswithIFT46(Cr),IFT88(Cr)IFT46(Cr,Mm),DYF-6(Ce),CG15161(Dm)StrongciliogenesisandanterogradeIFTdefect(Cr,Ce)/interactswithIFT52(Cr),IFT88(Cr),ODA16(Cr,Mm);transportsouterdyneinarms(ODA)intocilia(Cr)IFT27(Cr),RABL4(Mm),(absentinCe,Dm)Moderateciliogenesis(Cr);strongrepressiono...
