Seeonlineversionfor???158Cell144,January7,2010©2010ElsevierInc.DOI10.1016/j.cell.2010.12.024SnapShot:ChromatinRemodeling:INO80andSWR1YunheBaoandXuetongShenDepartmentofMolecularCarcinogenesis,M.D.AndersonCancerCenter,Smithville,TX78957,USASWR1RemodelingmechanismSWR1biologicalfunctionsINO80biologicalfunctionsINO80NucleosomeslidingATPADP+PiATPADP+PiATPADP+PiRepairfactorsRepairfactorsPINO80biologicalfunctionsINO80biologicalfunctionsRvb1,2TopviewSideviewStressconditionReplicationforkstabilizationDNAdamagetoleranceReplicationforkprogressionH2A.ZdepositionattheboundaryofeuchromatinandheterochromatinH2A.Zdepositionflankingnucleosome-freeregionaroundtranscriptionsiteLoadingofH2A.ZaroundDSBTranscriptionfactorsTranscriptionfactorsMRXRPAMec1XCheckpointfactorsCheckpointfactorsNormalcondition?DNArepairandcheckpointregulationTranscriptionrepressionandactivationH2A.ZH2BH2A.ZH2BH2AH2BFirstH2A.Z-H2BdimerexchangeSecondH2A.Z-H2BdimerexchangeAZZZAAIno80Swr1Ino80Swr1ActinActinArp4Arp4ActinActinArp4Arp4Swc2Swr1Swr1Swr1Swc2ActinActinArp4Arp4Swc2Swc2Act1SWR1INO80INO80INO80INO80SWR1SWR1PPPPPPPPActinActinArp4Arp4ActinActinArp4Arp4ActinActinArp4Arp4Swc2ActinActinArp4Arp4SIRAAATPADP+PiIno80ActinActinActinActinArp4Arp4Arp4Arp4Arp4ActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinActinNucleosomeslidingFirstH2A.Z-H2BAZSecondH2A.Z-H2BZZDNAdamagetoleranceStressStressReplisomeDNAdamagetoleranceDNAdamagetoleranceDNAdamagetoleranceDNAdamagetoleranceINO80INO80INO80INO80ReplisomeReplisomeINO80INO80ReplicationforkprogressionReplisomeRPAReplicationforkprogressionReplicationforkprogressionReplicationforkprogressionReplicationforkprogressionINO80ReplicationforkprogressionRPAINO80ReplicationforkprogressionReplisomeReplisomeNormalcondition?NormalINO80INO80INO80INO80INO80INO80CheckpointReplicationforkstabilizationDNAdamagetolerancePDNArepairandcheckpointregulationDNArepairandcheckpointregulatio...
