CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyHistoneLysineMethylationTranscriptionallyInactiveChromatinTranscriptionallyActiveChromatinSUV39hMeHP1SUV39hMeHP1SUV39hMeHP1SUV39hMeHP1MePCPRC1MePCPRC1MePCPRC1MePCPRC1MeBPTFNURFMeBPTFNURFMeMeMeMeMeMeMeMeMeMeMeMeMeMePericentricHeterochromatinInactiveXChromosomeRb-MediatedRepressionPericentricHeterochromatinInactiveXChromosomeHoxGeneRepressionAnti-SilencingTranscriptionInitiationTranscriptionElongationMethylationH3K9meDemethylationMethylationDemethylationMethylationH4K20meDemethylationMethylationH3K27meDemethylationMethylationH3K79meDemethylationMethylationH3K4meDemethylationH3K36meH3K4meMethylases:MLL1/KMT2A(+,†,‡)MLL2/KMT2B(+,†,‡)MLL3/KMT2C(+)MLL4/KMT2D(+)SET1A/KMT2F(+,†,‡)SET1B/KMT2G(+,†,‡)NSD3/KMT3F(+,†)NSD2/KMT3G(+,†)SET7/KMT7(†)SMYD3/KMT3E(†,‡)ASH1L/KMT2H(+,†,‡)PRDM9/KMT8B(‡)Demethylases:LSD1/KDM1A(+,†)AOF1/KDM1B(+,†)JARID1A/KDM5A(†,‡)JARID1B/KDM5B(†,‡)JARID1C/KDM5C(†,‡)JARID1D/KDM5D(†,‡)MethylationDegree:+Mono†Di‡TriH4K20meMethylases:SET8/KMT5A(+)NSD1/KMT3B(+,†)ASH1L/KMT2H(+,†,‡)SUV420H1/KMT5B(†,‡)SUV420H2/KMT5C(†,‡)NSD2/KMT3G(+,†)Demethylases:JHDM1D/KDM7A(+,†)PHF8/KDM7B(+,†)H3K9meMethylases:PRDM3/KMT8E(+)PPRDM16/KMT8F(+)G9a/EHMT2/KMT1C(+,†)EHMT1/KMT1D(+,†)ASH1L/KMT2H(+,†,‡)PRDM2/KMT8A(+,†,‡)PRDM8/KMT8D(†)SUV39H1/KMT1A(†,‡)SUV39H2/KMT1B(†,‡)ESET/KMT1E(†,‡)CLLD8/KMT1F(†,‡)Demethylases:AOF1/KDM1B(+,†)JMJD1A/KDM3A(+,†)JMJD1B/KDM3B(+,†)JMJD1C/KDM3C(+,†)JHDM1D/KDM7A(+,†)PHF8/KDM7B(+,†)JMJD2A/KDM4B(†,‡)JMJD2B/KDM4B(†,‡)JMJD2C/KDM4C(†,‡)JMJD2D/KDM4D(†,‡)KDM4E/KDM4DL(†,‡)H3K27meMethylases:Ezh2/KMT6(+,†,‡)NSD2/KMT3G(+,†,‡)NSD3/KMT3F(†,‡)Demethylases:JHDM1D/KDM7A(+,†)PHF8/KDM7B(+,†)UTX/KDM6A(†,‡)JMJD3/KDM6B(†,‡)H3K36meMethylases:NSD1/KMT3B(+,†)SMYD2/KMT3C(+,†)NSD2/KMT3G(+,†)SET2/KMT3A(‡)Demethylases:JMJD1A/KDM2A(+,†)JMJD1B/KDM2B(+,†)JMJD2A/KDM4A(†,‡)JMJD2B/KDM4B(†,‡)JMJD2C/KDM4C(†,‡)JMJD2D/KDM4D(†,‡)KDM4DL/KDM4E(†,‡)H3K79meMethylases:DOTIL/KMT4(+,†,‡)Demethylases:???
