ImmunologicalReviews.2020;00:1–12.|1wileyonlinelibrary.com/journal/imr1|GENERALINTRODUCTIONONANTIGENRECOGNITIONBYγδTCELLSHumanγδTlymphocytesaretypicallyclassifiedbasedontheVδchainusedtomaketheirTcellreceptor(TCR).Theprevalent(>70%)γδTlymphocytesinhumanbloodandsecondarylymphoidorgansofadultindividualsexpressaTCRheterodimercomposedoftheVγ9andVδ2chains.1ThesecellsarecommonlynamedasVγ9Vδ2Tlymphocytes,andrecognizenon-proteicpyrophosphatemetabolitescalledphosphoantigens(PAgs),whichderiveeitherfromthemeva-lonicacid(MVA)pathway2orthemicrobialnon-mevalonateRohmercycle((E)-4-hydroxy-3-methylbut-2-enylpyrophosphate,HMB-PP).3Butyrophilin-3A1(CD277)isnecessarybutnotsufficientforPAgrecognitionbyVγ9Vδ2Tcells.4-6AnotherBTNmole-cule,BTN2A1,hasbeenrecentlyidentifiedasakeyligandthatReceived:15April2020|Revised:21June2020|Accepted:30June2020DOI:10.1111/imr.12904INVITEDREVIEWDecipheringhumanγδTcellresponseincancer:Lessonsfromtumor-infiltratingγδTcellsElenaLoPresti1,2|FrancescoDieli1,2|JeanJacquesFourniè3,4,5,6,7|SerenaMeraviglia1,2©2020JohnWiley&SonsA/S.PublishedbyJohnWiley&SonsLtdThisarticleispartofaseriesofreviewscoveringγδTCellsappearinginVolume298ofImmunologicalReviews.1CentralLaboratoryofAdvancedDiagnosisandBiomedicalResearch(CLADIBIOR),UniversityofPalermo,Palermo,Italy2DepartmentofBiomedicine,NeurosciencesandAdvancedDiagnosis(BIND),UniversityofPalermo,Palermo,Italy3CentredeRecherchesenCancérologiedeToulouse,Toulouse,France4ToulouseUniversity,Toulouse,France5ERL5294CNRS,Toulouse,France6InstitutUniversitaireduCancer-OncopoledeToulouse,Toulouse,France7Laboratoired’Excellence‘TOUCAN’,Toulouse,FranceCorrespondenceFrancescoDieliandSerenaMeraviglia,CentralLaboratoryofAdvancedDiagnosisandBiomedicalResearch(CLADIBIOR),UniversitàdiPalermo,ViadelVespro129,Palermo90127,Italy.Emails:francesco.dieli@unipa.it;serena.meraviglia@unipa.itFundinginformationLabEXTOUCAN2;CentreNationaldelaRechercheScientifique;InstitutNationaldelaSantéetdelaRechercheMédicale;ItalianMini...
