JournalPre-proofAtaGlance:AHistoryofAutophagyandCancerXinWen,DanielJ.KlionskyPII:S1044-579X(19)30167-1DOI:https://doi.org/10.1016/j.semcancer.2019.11.005Reference:YSCBI1718Toappearin:SeminarsinCancerBiologyReceivedDate:4June2019RevisedDate:10October2019AcceptedDate:5November2019Pleasecitethisarticleas:WenX,KlionskyDJ,AtaGlance:AHistoryofAutophagyandCancer,SeminarsinCancerBiology(2019),doi:https://doi.org/10.1016/j.semcancer.2019.11.005ThisisaPDFfileofanarticlethathasundergoneenhancementsafteracceptance,suchastheadditionofacoverpageandmetadata,andformattingforreadability,butitisnotyetthedefinitiveversionofrecord.Thisversionwillundergoadditionalcopyediting,typesettingandreviewbeforeitispublishedinitsfinalform,butweareprovidingthisversiontogiveearlyvisibilityofthearticle.Pleasenotethat,duringtheproductionprocess,errorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.©2019PublishedbyElsevier.1AtaGlance:AHistoryofAutophagyandCancerXinWen1,DanielJ.Klionsky1*klionsky@umich.edu1LifeSciencesInstituteandDepartmentofMolecular,CellularandDevelopmentalBiology,UniversityofMichigan,AnnArbor,Michigan48109,USA*Correspondenceto:DanielJ.Klionsky(e-mail:)Keywords:ATG,autophagy,cancer,lysosome,stress,tumorAbstractSincethefirstdiscoveryofthelysosomeandthedefinitionofautophagybyChristiandeDuvemorethan60yearsago,researchonautophagy,aprocesstargetingcytoplasmicmaterialsforlysosomaldegradationandrecycling,hasexpandeddramatically.Thisresearchhasextendedourunderstandingofthebasicmechanismofautophagyaswellasitsroleinpathophysiology.Autophagydeficiencyhasbeenreportedtobeinvolvedinnumerousdiseases,amongwhichcancerhasbeenextensivelystudied,inpartbecauseautophagyappearstoplayadualrole,dependingonthestageoftumorigenesis.Inthisreview,wewillbrieflyrevisittheintriguinghistoryofautophagyandcancer,underscoringtheimportanceofharnessingthispathwayforthebenefitofhumanhealth.1.IntroductionAutophagy,meaning“self-eating”,isahighlyregulatedcellularprimarilycatab...
