Seeonlineversionforlegendandreferences.764Cell135,November14,2008©2008ElsevierInc.DOI10.1016/j.cell.2008.10.039SnapShot:Cell-CycleRegulatorsIDavidO.MorganUniversityofCalifornia,SanFrancisco,CA94143,USAfunctionPhaseS.cerevisiae(BuddingYeast)S.pombe(fissionYeast)D.melanogaster(fruitfly)X.laevis(clawedToad)H.sapiens(Human)Cyclin-dependentkinases(Cdks)Proteinkinasecatalyticsubunit,inactiveunlessboundtocyclinandphosphorylatedbyCAKcdk1(Cdc28):allstagescdk1(Cdc2):allstagescdk1(Cdc2):Mphasecdk1(Cdc2):Mphasecdk1(Cdc2):Mphasecdk2(Cdc2c):G1/S,S,possiblyMcdk2:G1/S,Scdk2:G1/S,Scdk4:G1,growthregulationcdk4:G1cdk4,cdk6:G1CyclinsStage-specificactivatorsofCdkcatalyticsubunitsG1cln3(bindsCdk1)Puc1?(bindsCdk1)cyclinD(bindsCdk4)cyclinD(bindsCdk4)cyclinD1,D2,D3(bindCdk4orCdk6)G1/Scln1,2(bindCdk1)Puc1,cig1?(bindCdk1)cycline(bindsCdk2)cycline(bindsCdk2)cycline(bindsCdk2)Sclb5,6(bindCdk1)cig2,cig1?(bindCdk1)cyclinA(bindsCdk1)cyclinA1,A2(bindCdk2,Cdk1)cyclinA1,A2(bindCdk2,Cdk1)Mclb1,2,3,4(bindCdk1)cdc13(bindsCdk1)cyclinB,B3(bindCdk1)cyclinB1,B2(bindCdk1)cyclinB1,B2(bindCdk1)Cdk-activatingkinase(CAK)PhosphorylatesCdksubunitatsinglethreonineinactivesite;requiredforfullCdkactivitymonomericcak1(Civ1)csk1Cdk-relatedMcs6(+cyclinMcs2)cdk7(+cyclinH)cdk7(+cyclinH)cdk7(+cyclinH)APC(anaphase-promotingcomplex)ubiquitinligase-activatingsubunitsStage-specificactivatorsofmultisubunitAPCcoreAnaphaseonsetcdc20slp1fizzy(Fzy)cdc20(p55CDC,Fizzy)LateM,G1cdh1(Hct1)srw1(Ste9)fizzy-related(Fzr,Rap)cdh1(Fizzy-related)MeiosisAma1Mfr1cortex?764.e1Cell135,November14,2008©2008ElsevierInc.DOI10.1016/j.cell.2008.10.040SnapShot:Cell-CycleRegulatorsIDavidO.MorganUniversityofCalifornia,SanFrancisco,CA94143,USAProgressionthroughtheeukaryoticcellcycleisgovernedbyacomplexregulatorysystemwhosecentralcomponentisthecyclin-dependentkinase(Cdk).TheyeastcellcycleiscontrolledbyasingleCdkcalledCdk1,whereasanimalcellsemployasmallfamilyofCdks,withCdk1andCdk2beingthekeyplayers.Cdkactivationrequiresas-sociationwithacyclinsubunit,aswe...
