CACANCERJCLIN2020;70:7–307VOLUME70|NUMBER1|JANUARY/FEBRUARY2020Abstract:Eachyear,theAmericanCancerSocietyestimatesthenumbersofnewcan-cercasesanddeathsthatwilloccurintheUnitedStatesandcompilesthemostrecentdataonpopulation-basedcanceroccurrence.Incidencedata(through2016)werecollectedbytheSurveillance,Epidemiology,andEndResultsProgram;theNationalProgramofCancerRegistries;andtheNorthAmericanAssociationofCentralCancerRegistries.Mortalitydata(through2017)werecollectedbytheNationalCenterforHealthStatistics.In2020,1,806,590newcancercasesand606,520cancerdeathsareprojectedtooccurintheUnitedStates.Thecancerdeathrateroseuntil1991,thenfellcontinuouslythrough2017,resultinginanoveralldeclineof29%thattrans-latesintoanestimated2.9millionfewercancerdeathsthanwouldhaveoccurredifpeakrateshadpersisted.Thisprogressisdrivenbylong-termdeclinesindeathratesforthe4leadingcancers(lung,colorectal,breast,prostate);however,overthepastdecade(2008-2017),reductionsslowedforfemalebreastandcolorectalcancers,andhaltedforprostatecancer.Incontrast,declinesacceleratedforlungcancer,from3%annuallyduring2008through2013to5%during2013through2017inmenandfrom2%toalmost4%inwomen,spurringthelargesteversingle-yeardropinoverallcancermortalityof2.2%from2016to2017.Yetlungcancerstillcausedmoredeathsin2017thanbreast,prostate,colorectal,andbraincancerscombined.Recentmor-talitydeclineswerealsodramaticformelanomaoftheskininthewakeofUSFoodandDrugAdministrationapprovalofnewtherapiesformetastaticdisease,escalatingto7%annuallyduring2013through2017from1%during2006through2010inmenandwomenaged50to64yearsandfrom2%to3%inthoseaged20to49years;annualdeclinesof5%to6%inindividualsaged65yearsandolderareparticularlystrikingbecauseratesinthisagegroupwereincreasingpriorto2013.Itisalsonota-blethatlong-termrapidincreasesinlivercancermortalityhaveattenuatedinwomenandstabilizedinmen.Insummary,slowingmomentumforsomecancersamena-bletoearlydetectionisjuxtaposedwithnotablegainsforothercommoncancers.CACancerJClin2020;70:7-30.©2020AmericanCancer...
