CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyAutophagySignalingAtg16L1PI3K-I/AktSignalingp53/GenotoxicStressPhagophoreAutophagosomeLysosomeCytoplasmicContentsMitochondrialDamageOxidativeStress-targetsSequestrationFusionAutophagolysosomeMembraneNucleationMAPK/Erk1/2SignalingAminoAcidsApoptosisRaptorMacroautophagyMitophagyGβLPRAS40Beclin-1PI3KClassIIIAMPKLC3-IPE++LC3LC3-IIAtg5Atg14Ambra1RubiconAtg5Atg12Atg12Atg7Bcl-2mTORp150PARLBNIP3PINKParkinAtg16L1Atg10Atg3SQSTM1/p62NBR1ALFY+LC3-IISQSTM1/p62NBR1Ambra1Atg4Atg7ULK1Atg13FIP200AMP:ATPububububBNIP3L/NIX
