ContentslistsavailableatScienceDirectSeminarsinCancerBiologyjournalhomepage:www.elsevier.com/locate/semcancerReviewTumourmicroenvironmentandmetabolicplasticityincancerandcancerstemcells:PerspectivesonmetabolicandimmuneregulatorysignaturesinchemoresistantovariancancerstemcellsNuzhatAhmeda,b,c,d,⁎,RuthEscalonaa,c,d,DilysLeunga,EmilyChand,GeorgeKannourakisa,baFionaElseyCancerResearchInstitute,Ballarat,Victoria,3353,AustraliabFederationUniversityAustralia,Ballarat,Victoria,3010,AustraliacTheHudsonInstituteofMedicalResearch,Victoria,3168,AustraliadDepartmentofObstetricsandGynaecology,UniversityofMelbourne,Victoria,3052,AustraliaARTICLEINFOKeywords:OvariancarcinomaTumourcellsCancerstemcellsAscitesChemoresistanceImmunecellsCancer-associatedfibroblastsEndothelialcellsABSTRACTCancerstemcells(CSCs)areasub-populationoftumourcells,whichareresponsibletodrivetumourgrowth,metastasisandtherapyresistance.Ithasrecentlybeenproposedthatenhancedglucosemetabolismandimmuneevasionbytumourcellsarelinked,andaremodulatedbythechangingtumourmicroenvironment(TME)thatcreatesacompetitionfornutrientconsumptionbetweentumouranddifferentsub-typesofcellsattractedtotheTME.Tofacilitateefficientnutrientdistribution,oncogene-inducedinflammatorymilieuinthetumoursfacil-itateadaptivemetabolicchangesinthesurroundingnon-malignantcellstosecretemetabolitesthatareusedasalternativenutrientsourcesbythetumourstosustainitsincreasingenergyneedsforgrowthandanabolicfunctions.ThisscenarioalsoaffectsCSCsresidingattheprimaryormetastaticniches.ThisreviewsummarisesrecentadvancesinourunderstandingofthemetabolicphenotypesofcancercellsandCSCsandhowtheseprocessesareaffectedbytheTME.WealsodiscusshowtheevolvingTMEmodulatestumourcellsandCSCsincancerprogression.Usingpreviouslydescribedproteomicandgenomicplatforms,ovariancancercelllinesandamousexenograftmodelwehighlighttheexistenceofmetabolicandimmuneregulatorysignaturesinche-moresistantovarianCSCs,anddiscusshowtheseprocessesmayaffectrecurrenceinovariantumours.Weproposethatprogres...
