FEMSMicrobiologyReviews,fuy037,43,2019,19–52doi:10.1093/femsre/fuy037AdvanceAccessPublicationDate:18October2018ReviewArticleREVIEWARTICLEConservationanddiversityofradiationandoxidativestressresistancemechanismsinDeinococcusspeciesSangyongLim1,Jong-HyunJung1,LaurenceBlanchard2andArjandeGroot2,∗,†1BiotechnologyResearchDivision,KoreaAtomicEnergyResearchInstitute,Jeongeup56212,RepublicofKoreaand2AixMarseilleUniv,CEA,CNRS,BIAM,SaintPaul-Lez-Durance,France∗Correspondingauthor:DRF/BIAM/LBC,UMR7265CEA-CNRS-AMUCEA,Cadarache,13108SaintPaulLezDurance,France.Tel:+330442253935;Fax:+330442254701;E-mail:nicolaas.degroot@cea.frOnesentencesummary:TheauthorsreviewedthemechanismsandfactorsinvolvedintheextremeradiationandoxidativestressresistanceinDeinococcusradioduransincomparisonwith10otherresistantDeinococcusspecies,andhighlightednotonlyconservedpathwaysbutalsoalargediversityoftherepair,protectionandregulationtoolboxamongthedifferentdeinococci.Editor:KennGerdes†ArjandeGroot,http://orcid.org/0000-0003-2202-5279ABSTRACTDeinococcusbacteriaarefamousfortheirextremeresistancetoionisingradiationandotherDNAdamage-andoxidativestress-generatingagents.Morethanahundredgeneshavebeenreportedtocontributetoresistancetoradiation,desiccationand/oroxidativestressinDeinococcusradiodurans.TheseencodeproteinsinvolvedinDNArepair,oxidativestressdefence,regulationandproteinsofyetunknownfunctionorwithanextracytoplasmiclocation.Here,weanalysedtheconservationofradiationresistance-associatedproteinsinotherradiation-resistantDeinococcusspecies.Strikingly,homologuesofdozensoftheseproteinsareabsentinoneormoreDeinococcusspecies.Forexample,onlyafewDeinococcus-specificproteinsandradiationresistance-associatedregulatoryproteinsarepresentineachDeinococcus,notablythemetallopeptidase/repressorpairIrrE/DdrOthatcontrolstheradiation/desiccationresponseregulon.Inversely,someDeinococcusspeciespossessproteinsthatD.radioduranslacks,includingDNArepairproteinsconsistingofnoveldomaincombinations,translesionpolymerases,addi...
