ArticleComplement-RelatedRegulatesAutophagyinNeighboringCellsGraphicalAbstractHighlightsdMacroglobulincomplement-related(Mcr)functionsinsalivaryglandcelldeathdMcrregulatescelldeathbyinfluencingautophagyinneighboringcellsdMcrisrequiredinepithelialcellsformacrophagemigrationtoepithelialwoundsdMcrfunctioninepithelialcellsisrequiredformacrophageautophagyAuthorsLinLin,FredericoS.L.M.Rodrigues,ChristinaKary,...,RichardH.G.Baxter,WillWood,EricH.BaehreckeCorrespondenceeric.baehrecke@umassmed.eduInBriefAcomplementorthologinDrosophilaplaysanessentialroleduringdevelopmentalcelldeathandinflammationbyinfluencingautophagyinneighboringcells.Linetal.,2017,Cell170,158–171June29,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.06.018ArticleComplement-RelatedRegulatesAutophagyinNeighboringCellsLinLin,1,2FredericoS.L.M.Rodrigues,3ChristinaKary,1,6AliciaContet,4MaryLogan,5RichardH.G.Baxter,4WillWood,3andEricH.Baehrecke1,7,*1DepartmentofMolecular,CellandCancerBiology,UniversityofMassachusettsMedicalSchool,Worcester,MA01605,USA2DepartmentofEmbryology,CarnegieInstitutionforScience,3520SanMartinDr.,Baltimore,MD21218,USA3SchoolofCellularandMolecularMedicine,FacultyofBiomedicalSciences,UniversityofBristol,UniversityWalk,BristolBS81TD,UK4DepartmentofChemistryandMolecularBiophysics&Biochemistry,YaleUniversity,NewHaven,CT06520,USA5Junger’sCenterforNeurosciencesResearch,DepartmentofNeurology,OregonHealthandScienceUniversity,3181SWSamJacksonParkRoad,Portland,OR97239,USA6Presentaddress:NatureCellBiology,OneNewYorkPlaza,NewYork,NY10004,USA7Leadcontact*Correspondence:eric.baehrecke@umassmed.eduhttp://dx.doi.org/10.1016/j.cell.2017.06.018SUMMARYAutophagydegradescytoplasmiccomponentsandisimportantfordevelopmentandhumanhealth.Althoughautophagyisknowntobeinfluencedbysys-temicintercellularsignals,theproteinsthatcontrolautophagyarelargelythoughttofunctionwithinindi-vidualcells.Here,wereportthatDrosophilamacro-globulincomplement-related(Mcr),acomplementortholog,playsanessentialroleduringdeve...
