CancerStatistics,2018RebeccaL.Siegel,MPH1*;KimberlyD.Miller,MPH2;AhmedinJemal,DVM,PhD3Abstract:Eachyear,theAmericanCancerSocietyestimatesthenumbersofnewcancercasesanddeathsthatwilloccurintheUnitedStatesandcompilesthemostrecentdataoncancerincidence,mortality,andsurvival.Incidencedata,availablethrough2014,werecollectedbytheSurveillance,Epidemiology,andEndResultsPro-gram;theNationalProgramofCancerRegistries;andtheNorthAmericanAssociationofCentralCancerRegistries.Mortalitydata,availablethrough2015,werecollectedbytheNationalCenterforHealthStatistics.In2018,1,735,350newcancercasesand609,640cancerdeathsareprojectedtooccurintheUnitedStates.Overthepastdecadeofdata,thecancerincidencerate(2005-2014)wasstableinwomenanddeclinedbyapproximately2%annuallyinmen,whilethecancerdeathrate(2006-2015)declinedbyabout1.5%annuallyinbothmenandwomen.Thecombinedcancerdeathratedroppedcontinuouslyfrom1991to2015byatotalof26%,trans-latingtoapproximately2,378,600fewercancerdeathsthanwouldhavebeenexpectedifdeathrateshadremainedattheirpeak.Ofthe10leadingcausesofdeath,onlycancerdeclinedfrom2014to2015.In2015,thecancerdeathratewas14%higherinnon-Hispanicblacks(NHBs)thannon-Hispanicwhites(NHWs)overall(deathrateratio[DRR],1.14;95%confidenceinterval[95%CI],1.13-1.15),buttheracialdisparitywasmuchlargerforindividualsaged<65years(DRR,1.31;95%CI,1.29-1.32)comparedwiththoseaged�65years(DRR,1.07;95%CI,1.06-1.09)andvariedsubstantiallybystate.Forexample,thecancerdeathratewaslowerinNHBsthanNHWsinMassachusettsforallagesandinNewYorkforindividualsaged�65years,whereasforthoseaged<65years,itwas3timeshigherinNHBsintheDistrictofColumbia(DRR,2.89;95%CI,2.16-3.91)andabout50%higherinWisconsin(DRR,1.78;95%CI,1.56-2.02),Kansas(DRR,1.51;95%CI,1.25-1.81),Louisiana(DRR,1.49;95%CI,1.38-1.60),Illinois(DRR,1.48;95%CI,1.39-1.57),andCalifornia(DRR,1.45;95%CI,1.38-1.54).Largerracialinequalitiesinyoungandmiddle-agedadultsprobablypartlyreflectlessaccesstohigh-qualityhealthcare.CACancerJClin2018;000:000-000.VC2018AmericanCancerSociety....