ArticleAGeneticVariantAssociatedwithFiveVascularDiseasesIsaDistalRegulatorofEndothelin-1GeneExpressionGraphicalAbstractHighlightsdAnon-codingvariantonchromosome6associateswithfivevasculardiseasesdHistoneacetylationshowsavascular-specificregulatoryelementatthecausalSNPdGenomeeditingattheSNPdemonstratesdistalregulatoryeffectonendothelin-1dEndothelin-1signalinginbloodvesselsmayexplainpatternofvasculardiseaseriskAuthorsRajatM.Gupta,JosephHadaya,AditiTrehan,...,RenateB.Schnabel,BradleyE.Bernstein,SekarKathiresanCorrespondencergupta@broadinstitute.org(R.M.G.),skathiresan1@mgh.harvard.edu(S.K.)InBriefAcommonsequencevariantthatperturbslong-rangeenhancerinteractionsmediatesriskfordifferentvasculardiseases.Guptaetal.,2017,Cell170,522–533July27,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.06.049ArticleAGeneticVariantAssociatedwithFiveVascularDiseasesIsaDistalRegulatorofEndothelin-1GeneExpressionRajatM.Gupta,1,2,3,8,*JosephHadaya,1AditiTrehan,1SeyedehM.Zekavat,1CarolinaRoselli,1DerekKlarin,1ConnorA.Emdin,1CatharinaR.E.Hilvering,4ValerioBianchi,4ChristianMueller,6AmitV.Khera,1,2,3RussellJ.H.Ryan,1,5JesseM.Engreitz,1RobbynIssner,1NoamShoresh,1CharlesB.Epstein,1WouterdeLaat,4JonathanD.Brown,7RenateB.Schnabel,6BradleyE.Bernstein,1,5andSekarKathiresan1,2,3,*1BroadInstituteofMITandHarvardUniversity,Cambridge,MA,USA2CardiologyDivision,DepartmentofMedicine,MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,MAUSA3CenterforGenomicMedicine,DepartmentofMedicine,MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,MA,USA4HubrechtInstitute,UniversityMedicalCenterUtrecht,Utrecht,theNetherlands5DepartmentofPathology,MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,MA,USA6DepartmentofGeneralandInterventionalCardiology,UniversityHeartCenterHamburg-Eppendorf,Hamburg,Germany7DivisionofCardiovascularMedicine,VanderbiltUniversityMedicalCenter,Nashville,TN,USA8LeadContact*Correspondence:rgupta@broadinstitute.org(R.M.G.),skathiresan1@mgh.harvard.edu(S.K.)http...
