Ageing, Age-related Diseases and Oxidative Str.pdfVIP免费

JournalPre-proofAgeing,Age-relatedDiseasesandOxidativeStress:WhattoDoNext?JiaoLuo,KevinMills,SaskialeCessie,RaymondNoordam,DianavanHeemstPII:S1568-1637(19)30174-6DOI:https://doi.org/10.1016/j.arr.2019.100982Reference:ARR100982Toappearin:AgeingResearchReviewsReceivedDate:7June2019RevisedDate:4October2019AcceptedDate:12November2019Pleasecitethisarticleas:LuoJ,MillsK,leCessieS,NoordamR,vanHeemstD,Ageing,Age-relatedDiseasesandOxidativeStress:WhattoDoNext?,AgeingResearchReviews(2019),doi:https://doi.org/10.1016/j.arr.2019.100982ThisisaPDFfileofanarticlethathasundergoneenhancementsafteracceptance,suchastheadditionofacoverpageandmetadata,andformattingforreadability,butitisnotyetthedefinitiveversionofrecord.Thisversionwillundergoadditionalcopyediting,typesettingandreviewbeforeitispublishedinitsfinalform,butweareprovidingthisversiontogiveearlyvisibilityofthearticle.Pleasenotethat,duringtheproductionprocess,errorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.©2019PublishedbyElsevier.Ageing,Age-relatedDiseasesandOxidativeStress:WhattoDoNext?JiaoLuo1,2,KevinMills3,SaskialeCessie1,4,RaymondNoordam2,DianavanHeemst21DepartmentofClinicalEpidemiology,LeidenUniversityMedicalCenter,Leiden,TheNetherlands2InternalMedicine,sectionGerontologyandGeriatrics,LeidenUniversityMedicalCenter,Leiden,TheNetherlands3BiochemistryResearchGroup,Clinical&MolecularGeneticsUnit,UniversityCollegeLondonInstituteofChildHealth,London,UK4DepartmentofMedicalStatisticsandBioinformatics,LeidenUniversityMedicalCenter,Leiden,TheNetherlandsCorrespondingauthor:DianaVanHeemst,E-mail:D.van_Heemst@lumc.nlHighlightsDamagecausedbyoxidativestressisanimportanthallmarkofageingWhereasexperimentalworkshowsclearantioxidanteffects,clinicaltrialsfailedThereisalackofreliablemarkersofoxidativestressinlargeepidemiologicalstudiesFunctionallevel,butnotcirculationlevel,ofantioxidantscouldprovidemoreinsightsAbstractAmongothermechanisms,oxidativestresshasbeenpostulatedtoplayanim...