AcceptedManuscriptTitle:Apromisingnewapproachtocancertherapy:TargetingironmetabolisminCancerStemCellsAuthors:MouradiElHout,Le¨ılaDosSantos,AhmedHama¨ı,MaryamMehrpourPII:S1044-579X(18)30051-8DOI:https://doi.org/10.1016/j.semcancer.2018.07.009Reference:YSCBI1496Toappearin:SeminarsinCancerBiologyReceiveddate:18-5-2018Reviseddate:24-7-2018Accepteddate:25-7-2018Pleasecitethisarticleas:ElHoutM,DosSantosL,Hama¨ıA,MehrpourM,Apromisingnewapproachtocancertherapy:TargetingironmetabolisminCancerStemCells,SeminarsinCancerBiology(2018),https://doi.org/10.1016/j.semcancer.2018.07.009ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.1Apromisingnewapproachtocancertherapy:TargetingironmetabolisminCancerStemCells.MouradiElHout1,2,LeïlaDosSantos1,2,AhmedHamaï1,2*,andMaryamMehrpour1,2*1InstitutNecker-EnfantsMalades(INEM),InsermU1151-CNRSUMR8253.2UniversitéParisDescartes-SorbonneParisCité,F-75993Paris,France.*maryam.mehrpour@inserm.fr&ahmed.hamai@inserm.frAbstract..........................................................................................................................................2Introduction...................................................................................................................................3CellularIronuptake,trafficking,andstorageinepithelialcells................................................3Cellularironhomeostasisregulation..........................................................................................5Ironmetabolismandcancer........................................................................................................6Effectofdietaryandsystemicironontumorigenesis........
